Results 31 to 40 of about 861,022 (290)

Effect of Repeated Loads on the Low Temperature Fracture Behavior of Notched and Welded Plates [PDF]

, 1967
The influence of repeated loadings on the susceptibility of weldments to fracture in a brittle manner is studied for an ABS-Class C steel. The test members have consisted primarily of 12, 24 and 36 in.
Cannon, J.P., Kiefner, J.F., Munse, W.H.
core  

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

The kinetics of phenol degradation by immobilized pseudomonas sp in a repeated-batch process [PDF]

, 2007
The best operating conditions for phenol degradation by immobilized Pseudomonas sp in packed column were determined, and then evaluated in repeated batch cultures. The maximum degradation rate occurred in i) the support with 1.0 cm diameter or less, ii)
Firdausi, R., Mailin, M.
core  

FAILURE OF ARCHES UNDER VARIABLE REPEATED LOADING

Transactions of the Japan Society of Civil Engineers, 1966
THE THEORETICAL ANALYSIS OF THE SHAKEDOWN LOADING OF STRUCTURES APPLYING A BENDING MOMENT AND AN AXIAL THRUST IS DESCRIBED, AND THE LOADS ARE CALCULATED FOR TWO HINGED STEEL CIRCULAR ARCHES WITH I, BOX, OR RECTANGULAR CROSS SECTIONS. THE CALCULATED RESULTS FOR CONCENTRATED, UNIFORMLY DISTRIBUTED, AND THEIR COMBINED LOADINGS ARE COMPARED FOR THE MINIMUM
Fukumoto, Yuhshi, Yoshida, Hiroshi
openaire   +2 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Repeated loading model for elastic–plastic contact of geomaterial

Advances in Mechanical Engineering, 2018
A new nonlinear hysteretic model with considering the loading, unloading, and reloading processes is developed based on Drucker–Prager yield criterion and finite-element analysis.
Jian Wang, Qimin Li, Changwei Yang, Caizhi Zhou   +3 more
doaj   +1 more source

A two-state kinetic model for the unfolding of single molecules by mechanical force [PDF]

, 2002
We investigate the work dissipated during the irreversible unfolding of single molecules by mechanical force, using the simplest model necessary to represent experimental data. The model consists of two levels (folded and unfolded states) separated by an
Bell, Bonnet, Bustamante, Bustamante, C. Bustamante, Cluzel, Evans, Evans, Evans, F. Ritort, Gallavotti, Hanggi, Hummer, I. Tinoco, Liphardt, Liphardt, Smith, Smith, Wang   +18 more
core   +3 more sources

A Systematic Evaluation of the Empirical Relationships Between the Resilient Modulus and Permanent Deformation of Pavement Materials

Buildings
The resilient modulus (Mr) and permanent deformation of subgrade soils are key indicators for assessing pavement performance under repeated traffic loads.
Zeping Yang, Junyu Sun, Yupeng Zhang, Jiarui Liu, Erwin Oh, Zhanguo Ma   +5 more
doaj   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source