Results 71 to 80 of about 3,681,265 (301)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Trend-resistant and cost-efficient cross-over designs for mixed models. [PDF]
A mixed model approach is used to construct optimal cross-over designs. In a cross-over experiment the same subject is tested at different points in time.
Tack, L, Vandebroek, Martina
core
, 2015 A common problem is to compare two cross-sectional estimates for the same study variable taken on two different waves or occasions, and to judge whether the change observed is statistically significant.
Berger, Yves G. +3 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structures and properties of repeated measurement designs
, 1984 In this study the structure and properties of repeated measurement (RM) designs are investigated from different points of view, such as (i) balancedness or partial balancedness, (ii) construction versus estimation, (iii) underlying linear models, (iv ...
Shing, Chen-Chi
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Isotone Optimization in R: Pool-Adjacent-Violators Algorithm (PAVA) and Active Set Methods
Journal of Statistical Software, 2009 In this paper we give a general framework for isotone optimization. First we discuss a generalized version of the pool-adjacent-violators algorithm (PAVA) to minimize a separable convex function with simple chain constraints.
Jan de Leeuw, Kurt Hornik, Patrick Mair
doaj
Resting metabolic rate fluctuations across the menstrual cycle: a systematic review
Frontiers in PhysiologyIntroductionThe aim of this systematic review was to evaluate the current evidence regarding resting metabolic rate fluctuations across menstrual cycle phases in healthy, naturally menstruating females.
Anežka Hurtová +2 more
doaj +1 more source
AIP Advances, 2020 Here, we report on the application of an electron source with high accelerating voltage (62 kV–200 kV) to simulate betavoltaic power generation capabilities of a planar GaN PIN (p-GaN/i-GaN/n-GaN) device.
Kasey Hogan +5 more
doaj +1 more source
Optimal designs for an interference model [PDF]
Kunert and Martin (2000) determined optimal and efficient block designs in a model for field trials with interference effects, for block sizes up to 4. In this paper we use Kushner's method (Kushner, 1997) of finding optimal approximate designs to extend
Kunert, Joachim, Mersmann, Sabine
core