Results 331 to 340 of about 2,176,828 (392)

Astragaloside IV Alleviates Ulcerative Colitis Progression by Inhibiting WDR5‐Mediated ENO1 H3K4me3 Modification

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ulcerative colitis (UC) has become a prevalent global health concern. This study scrutinized the influence of Astragaloside IV (ASI) on DSS‐induced UC, with particular emphasis on the role of WDR5 in mediating ENO1 expression. The therapeutic efficacy of ASI was assessed in a mouse model of UC by evaluating disease activity index, pathology ...
Su‐Xiao Wu, Zi‐Lan Chen, Xiao‐Hong Wang, Jie Gu   +3 more
wiley   +1 more source

Corrigendum: Paricalcitol alleviates intestinal ischemia-reperfusion injury via inhibition of the ATF4-CHOP pathway. [PDF]

Front Pharmacol
Zhang J, Liu T, Xue T, Jia Z.
europepmc   +1 more source

GATA1 Transcriptionally Upregulates LMCD1, Promoting Ferroptosis in Sepsis‐Associated Acute Kidney Injury Through the Hippo/YAP Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA‐AKI. Here, we investigated the role of LIM and cysteine‐rich domain 1 (LMCD1) in the regulation of ferroptosis during SA‐AKI progression.
You‐Qi Zhang, Wei‐Xia Peng, You‐Fu Li, Peng Lu, Hui Liu, Wen‐Guang Liu   +5 more
wiley   +1 more source

SFXN1 Reduction Alleviates Cerebral Ischemia-Reperfusion Injury by Promoting Neuronal Survival and Reducing Neuroinflammation. [PDF]

CNS Neurosci Ther
Xu X, Duan Z, Zhou X, Zhao R, Xu J, Zhang Z, Lv M, Wan Q, Cui Y.   +8 more
europepmc   +1 more source

Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism‐Like Behaviors in a Valproic Acid Induced Male Mouse Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated whether Ginsenoside Rg1 (Rg1) alleviates autism‐like behaviors in mice prenatally exposed to valproic acid (VPA) via Sirt2/Foxo1 signaling. Pregnant C57BL/6J mice received a single intraperitoneal injection of VPA (600 mg/kg) on embryonic Day 12.5 to establish an autism model.
Fan‐Xu Song, Qing‐Wei Wu, Wei Pan, Li‐Jun Liu, Xin Li, Xue Zhou, Zong‐Yao Yu, Xin Ning, Lan‐Min Guo   +8 more
wiley   +1 more source

The effect of nuciferine on the renal dysfunction following ischemia-reperfusion injury. [PDF]

PLoS One
Sallabi SM, Lubbad L, Toumi HR, Hammad WF, Sudhadevi M, Rasheed JA, Hammad AF, Ardah MM, Al-Salam S, Hammad FT.   +9 more
europepmc   +1 more source

Splenic modulation of the early inflammatory response to regional and global ischemia/reperfusion injury in swine. [PDF]

Am J Physiol Heart Circ Physiol
Rolland TJ, Hudson ER, Graser LA, Zahra S, Cucinotta D, Weil BR.   +5 more
europepmc   +1 more source

Natural product library screening identifies Darutigenol for the treatment of myocardial infarction and ischemia/reperfusion injury. [PDF]

Chin Med
Liu K, Zheng L, Huang QY, Li HJ, Li C, Zhao H, Ye ZB, Wang H, Qi XF, Wang M.   +9 more
europepmc   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source