Results 361 to 370 of about 2,176,828 (392)

Mechanisms of Reperfusion Injury

The American Journal of the Medical Sciences, 1994
Reperfusion of ischemic organs can result in tissue injury that is manifested as microvascular and parenchymal cell dysfunction. Reactive oxygen metabolites and polymorphonuclear leukocytes (PMN) have been implicated in the pathobiology of reperfusion injury.
D N Granger, B J Zimmerman
openaire   +2 more sources

Ischaemic conditioning and reperfusion injury [PDF]

Nature Reviews Cardiology, 2016
The 30-year anniversary of the discovery of 'ischaemic preconditioning' is in 2016. This endogenous phenomenon can paradoxically protect the heart from acute myocardial infarction by subjecting it to one or more brief cycles of ischaemia and reperfusion.
D. Hausenloy, D. Yellon
semanticscholar   +5 more sources

Cytokines and Reperfusion Injury

Journal of Cardiac Surgery, 1993
Myocardial dysfunction following prolonged ischemia and reperfusion is at least partially dependent upon adhesion of neutrophils to myocardial and endothelial cells. Neutrophils are thought to contribute to reperfusion injury by two mechanisms: impairment of the microvasculature by physical obstruction, and secretion of products that damage ...
openaire   +3 more sources

Renal ischaemia-reperfusion injury

British Journal of Surgery, 1996
Ischaemia-reperfusion injury is a complex interrelated sequence of events that classically involves the vascular endothelium and activated leucocytes. During the ischaemic phase the endothelium is primed both to produce free radicals and to secrete chemoattractants.
Weight, SC, Bell, PRF, Nicholson, ML
openaire   +4 more sources

Myocardial Reperfusion Injury

Critical Care Nursing Clinics of North America, 1990
A review of the mechanism of ischemic-reperfusion injury, proposed interventions to prevent injury, and future directions have been presented to enhance the practitioner's knowledge of this new, exciting concept in myocardial injury. There is increasing evidence in the literature that reperfusion injury may occur in other organ systems and is ...
openaire   +2 more sources

Ischemia and reperfusion injury [PDF]

Transplantation Reviews, 2003
Abstract Organ allografts, particularly from less than optimal donors, may not be biologically inert at the time of transplantation but may trigger or amplify subsequent host responses against the foreign tissues. These potentially activated organs may provoke a continuum between the inflammatory changes evoked in the recipient by initial nonspecific,
J Pratschke, M.J Wilhelm, Nicholas L. Tilney, Igor Laskowski   +3 more
openaire   +1 more source

Pathophysiology of reperfusion injury

2011
INTRODUCTION Ischaemia-Reperfusion Injury (IRI) is defined as the paradoxical exacerbation of cellular dysfunction and death, following restoration of blood flow to previously ischaemic tissues. Reestablishment of blood flow is essential to salvage ischaemic tissues.
Cowled, P., Fitridge, R.
openaire   +2 more sources

Cytokines and reperfusion injury

Neurology, 1997
There is increasing evidence that the inflammatory response plays an important role in the potentiation of central nervous system (CNS) ischemic injury. Much of this inflammatory response appears to be mediated by interleukins (IL), a multifunctional subclass of cytokines.
openaire   +3 more sources

Effects of taurine on reperfusion injury

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2011
Taurine is an organic acid, which has a very important function in the human body. Recently, the antioxidant property of taurine has been much emphasised. In this study, the gracilis muscle flap model was used to investigate the effect of taurine in ischaemia/reperfusion injury in rats.
Hede Y., Akdemir O., Zhang F., Lineaweaver W.C., Arslan Z., Songur E.   +5 more
openaire   +4 more sources

mTOR and Beclin1: Two key autophagy‐related molecules and their roles in myocardial ischemia/reperfusion injury

Journal of Cellular Physiology, 2019
Autophagy is the general term of lysosomal degradation of substances in cells, which is considered the key to maintaining the normal structure and function of the heart.
Binhao Shi, Mengqing Ma, Yitian Zheng, Yanyan Pan, Xianhe Lin   +4 more
semanticscholar   +1 more source