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Hyperoxia during reperfusion is a factor in reperfusion injury

Free Radical Biology and Medicine, 1989
Imposition of ischemia should result in accumulation of lactic acid with an attendant drop in pH. Subsequent reperfusion would result in hyperoxia, in the affected tissue, due to the Bohr Effect. O2- should therefore be produced in greater than normal amounts, due to this transient hyperoxia, and may contribute to reperfusion injury.
Irwin Fridovich, Myron L. Wolbarsht
openaire   +3 more sources

Ischemia/Reperfusion Injury

2003
Survival of traumatic abdominal injuries is essentially a 20th century development. Historically, abdominal wounds were left untreated because of a lack of anesthesia, and repairs were performed only in cases of evisceration. Even after the discovery of ether anesthesia in the mid-19th century, surgery remained controversial because of the documented ...
Terez Shea-Donohue   +2 more
openaire   +2 more sources

Reperfusion injury: A role for neutrophils [PDF]

open access: possibleHepatology, 1991
To determine the role of neutrophils in the pathogenesis of hepatic ischemia/reperfusion injury, livers from male Fischer rats were subjected to 45 min of no-flow ischemia followed by reperfusion for up to 24 h. Two phases of liver injury were identified, an initial phase during the first hour of reperfusion and a later ...
Ronald G. Thurman, John J. Lemasters
openaire   +2 more sources

Targeting autophagy in cardiac ischemia/reperfusion injury: A novel therapeutic strategy

Journal of Cellular Physiology, 2019
Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI.
M. Aghaei   +9 more
semanticscholar   +1 more source

'Myocardial Ischemia-Reperfusion Injury and the Influence of Inflammation.

Trends in cardiovascular medicine, 2022
M. Algoet   +6 more
semanticscholar   +1 more source

Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury

Neurochemical Research, 2022
Qian-ru Zhang   +4 more
semanticscholar   +1 more source

Mechanisms of myocardial reperfusion injury

The Annals of Thoracic Surgery, 1999
Reperfusion of the ischemic myocardium results in irreversible tissue injury and cell necrosis, leading to decreased cardiac performance. While early reperfusion of the heart is essential in preventing further tissue damage due to ischemia, reintroduction of blood flow can expedite the death of vulnerable, but still viable, myocardial tissue, by ...
James L. Park, Benedict R. Lucchesi
openaire   +3 more sources

ISCHAEMIA‐REPERFUSION INJURY TO THE INTESTINE

Australian and New Zealand Journal of Surgery, 1998
Ischaemia‐reperfusion injury (IRI) is of obvious relevance in situations where there is an interruption of blood supply to the gut, as in vascular surgery, or in the construction of free intestinal grafts. It is now appreciated that IRI also underlies the gut dysfunction that occurs in early shock, sepsis, and trauma.
John C. Hall   +4 more
openaire   +3 more sources

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