Results 101 to 110 of about 185,231 (352)

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Thrombolytic Therapy Up-regulates Inflammatory Mediators Compared to Percutaneous Coronary Intervention (PCI)

Iranian Journal of Allergy, Asthma and Immunology, 2016
The important role of reperfusion therapies in the treatment of acute myocardial infarction is well documented. However, reperfusion therapies can initiate inflammatory response and may damage the myocardium.
Alireza Garjani, Bahram Sohrabi, Ali Akbar Movassaghpour, Sina Andalib, Mehriar Shokri, Bahar Taherkhanchi, Bahador Bagheri   +6 more
doaj  

Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries [PDF]

, 2017
Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients ...
Agladze, Vaja, Alexopoulos, Dimitrios, Alhabib, Khalid F., Almeida, Manuel, Antoniades, Loizos, Antov, S., Babic, Z., Becker, David, Birkhead, John, Bjornsdottir, Thora K., Bovenzi, Francesco, Cavanagh, Brendan, Christodulides, Theodoros, Claeys, Marc J., Clemmensen, Peter, Cremonesi, Alberto, D'Angeli, Cinzia, Daly, Kieran, De Boer, Menko-Jan, De Luca, Leonardo, Deleanu, Dan, Di Mario, Carlo, Dobric, Milan, Dudek, Dariusz, Erglis, Andrejs, Erne, Paul, Ertas, Gokhan, Fajadet, Jean, Galatius, Søren, Georgiou, Panagiota, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hajric, R., Hansen, Kim Wadt, Hricak, V., Huber, Kurt, James, Stefan, Janota, Tomáš, Jansky, Petr, Jennings, Siobhan, Jorgova, Julia, Kaifoszova, Zuzana, Kajander, Olli, Kala, Petr, Kallikazaros, Ioannis, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kervan, Umit, Kiss, Robert Gabor, Koch, Karel T., Kornowski, Ran, Kovař, F., Kozan, Omer, Kristensen, Steen D., Kurray, P., Laut, Kristina G., Legrand, V., Ludman, Peter F., Maca, Aija, Markota, D., Matetzky, Shlomi, Merkely, Béla, Milicic, Davor, Mimoso, Jorge, Mühlberger, Volker, Müller, Alfred, Najafov, Ruslan, Najafov, Ruslan, Narbute, Inga, Nedeljkovic, Milan, Nicolaides, Evagoras, Nicolini, Francesca A., Nikolic Heitzler, V., Noč, Marko, Ostojic, Miodrag, Papaioannou, Georgios, Peral, Vincente, Pereira, Ernesto, Pereira, Hélder, Petrov, Ivo, Radovanovic, Dragana, Regueiro, Ander, Rickli, Hans, Romppanen, Hannu, Rustige, Jörg, Sabaté, Manel, Shal, Ahmed El, Skuladottir, Frida Bjork, Sobhy, Mohamed, Sobhy, Mohamed, Sokolov, Maxim, Sokolov, Yuriy, Spuzic, M., Srdic, S., Stasek, Josef, Studencan, Martin, Sørensen, Rikke, Tatu, Gabriel, Terkelsen, Christian Juhl, Terzic, Ibrahim, Tresserras, Ricard, Twomey, Kathleen, Ungi, Imre, Velchev, Vassil, Vinereanu, Dragos, Vukcevic, Vladan, Wahler, Steffen, Widimsky, Petr, Wijns, William, Windecker, Stephan, Zakke, IIja   +113 more
core  

Editor's choice : European Society for Vascular Surgery (ESVS) 2020 clinical practice guidelines on the management of acute limb ischaemia

, 2020
A
Acosta, Stefan, Azuma, Nobuyoshi, Bastos Gonçalves, Frederico, Björck, Martin, Boyle, Jonathan R., Chakfé, Nabil, Choke, Edward T. C., Cochennec, Frederic, Cohnert, Tina U., de Borst, Gert J., Document Reviewers, Earnshaw, Jonothan J., ESVS Guidelines Committee, Fitridge, Robert A., Forbes, Thomas L., Hamady, Mohamad S., Hinchliffe, Robert, Jongkind, Vincent, Kakkos, Stavros K., Koelemay, Mark J. W., Koncar, Igor, Lindholt, Jes S., Mani, Kevin, Menyhei, Gabor, Munoz, Alberto, Müller-Hülsbeck, Stefan, Rai, Kumud, Sebastian Debus, E., Svetlikov, Alexei V., Tshomba, Yamume, Tulamo, Riikka, van den Berg, Jos C., Vega de Ceniga, Melina, Vermassen, Frank   +33 more
core   +2 more sources

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Local generation of hydrogen for enhanced photothermal therapy. [PDF]

, 2018
By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise.
Chen, Danyang, Chen, Qian, Gu, Zhen, He, Qianjun, Jin, Zhaokui, Lu, Xifeng, Meng, Jin, Yang, Tian, Zhao, Penghe   +8 more
core   +2 more sources

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Anti-inflammatory Therapy Before Reperfusion Therapy in Patients with Ischemic Vascular Disease on the Incidence of Ischemic Reperfusion Injury: An Evidence-Based Case Report

Acta Medica Indonesiana
Background: Reperfusion serves as a mainstay therapy in almost all ischemic vascular diseases (IVD), but reperfusion may enhance cell damage after an ischemic period time.
Dono Antono, Ade Gautama, Nindya P.B.S Utami   +2 more
doaj   +2 more sources

Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]

, 2019
PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ, Hollmann, Markus W, Konkel, Moritz, Oei, Gezina TML, Patel, Hemal H, Preckel, Benedikt, Smit, Kirsten F, Weber, Nina C   +7 more
core   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source