Results 121 to 130 of about 182,452 (306)

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Subclinical Hyperthyroidism Could Predict Poor Outcomes in Patients With Acute Ischemic Stroke Treated With Reperfusion Therapy

Frontiers in Neurology, 2019
Background: Evidence for the effect of subclinical thyroid dysfunction on the prognosis of patients suffering from acute ischemic stroke and receiving reperfusion therapy remains controversial.
Sang-Hwa Lee, Min Uk Jang, Yerim Kim, So Young Park, Chulho Kim, Yeo Jin Kim, Jong-Hee Sohn   +6 more
doaj   +1 more source

Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of asphyxia induced-cardiac arrest. [PDF]

, 2019
Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes in a rat model of global brain
Alexander, Bahjat, Bell, Chan, Cohan, Cui, Cui, Ge, Guo, Hayashida, Hayashida, Huang, Huang, Ji, Katsumata, Li, Lim, Moulaert, Nagatani, Neigh, Ohsawa, Ono, Reis, Roine, Schuhmann, Sugawara, Tamura, Tamura, Tian, Volpe, Wang, Xie, Zhao   +32 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Reperfusion therapy in inferior myocardial infarction

Journal of the American College of Cardiology, 1988
This review summarizes the multicenter trial results of reperfusion therapy for treatment of inferior myocardial infarction. Therapy with intracoronary streptokinase or intravenous recombinant tissue plasminogen activator (rt-PA) produced higher patency rates than did intravenous streptokinase. Reocclusion was more common when the right coronary artery
openaire   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

大动脉粥样硬化性缺血性卒中再灌注治疗的研究进展 Research Progress of Reperfusion Therapy for Large Artery Atherosclerotic Ischemic Stroke

Zhongguo cuzhong zazhi
急性缺血性卒中是一种严重威胁人类健康的疾病，其中大动脉粥样硬化性卒中症状更重，预后更差，再灌注治疗可有效改善这类患者的功能预后。近年来再灌注治疗技术发展迅速，但也面临一些挑战，如治疗时间窗内患者比例低、再灌注损伤、出血转化等。要解决这些问题，需要从多个层面采取对策，如优化急救流程、革新操作技术、加强损伤防护等。本文对大动脉粥样硬化性缺血性卒中再灌注治疗面临的挑战和对策进行了初步讨论。 Abstract: Acute ischemic stroke is a serious disease that ...
符鹏程1*，曹黎明2*，朱佳倩1，3，赵桂玉1，徐格林1（*第一作者）(FU Pengcheng1*, CAO Liming2*, ZHU Jiaqian1,3, ZHAO Guiyu1, XU Gelin1 (*contributed equally). )
doaj   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source