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The Use of Fibrinolytic Agents in the Salvage of Free Flaps: A Systematic Review [PDF]

Journal of Personalized Medicine
Background: Microvascular thrombosis following free tissue transfer presents a complex challenge for surgeons and carries the potential risk of flap failure. The application of fibrinolytic agents represents a robust therapeutic option.
Christian Smolle, Patrick Mandal, Andrzej Hecker   +2 more
exaly   +3 more sources

Combining antithrombotic and fibrinolytic agents: can it be done? [PDF]

Stroke, 2013
More than half of ischemic stroke patients who are treated with IV recombinant tissue-type plasminogen activator (rtPA) remain disabled at 3 months.1,2 The reasons are many. The IV rtPA rate of recanalizing occluded arteries is not as high as we would like, especially for large arterial occlusions, which are opened only 30% to 40% of the time.3–6 When ...
Khatri P, Mono ML.
europepmc   +4 more sources

Prospects of fibrinolytic proteases of bacteria from sea cucumber fermentation products as antithrombotic agent

BIO Web of Conferences, 2020
Cardiovascular disease is among the largest contributors of premature mortality in the world caused by inflammation of blood vessels. The abnormalities provoke thrombus formation or thrombosis blocking blood vessels leading to strokes, heart attacks and ...
Fuad Hayatun, Hidayati Nur, Darmawati Sri, Munandar Hendra, Rahmawati Sulistyaningtyas Ayu, Nurrahman Nurrahman, Rahman Ernanto Aditya, Seswita Zilda Dewi, Widjanarka Widjanarka, Norma Ethica Stalis   +9 more
doaj   +2 more sources

Fibrinolytic agents for peripheral arterial occlusion. [PDF]

Cochrane Database Syst Rev, 2013
Peripheral arterial thrombolysis is used in the management of peripheral arterial ischaemia. Streptokinase was originally used but safety concerns led to a search for other agents. Urokinase and recombinant tissue plasminogen activator (rt-PA) have increasingly become established as first line agents for peripheral arterial thrombolysis.
Robertson I, Kessel DO, Berridge DC.
europepmc   +4 more sources

Intrapleural Fibrinolytic Therapy in the Management of Pediatric Pleural Empyema: A Narrative Review [PDF]

Pharmaceuticals
Background: Pediatric pleural empyema is a major complication of community-acquired pneumonia and remains associated with substantial morbidity despite advances in vaccination, antimicrobial therapy, and supportive care. Intrapleural fibrinolytic therapy
Susanna Esposito, Valentina Fainardi, Gaia Giorgia Arnesano, Nicola Principi   +3 more
doaj   +2 more sources

Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury

Frontiers in Immunology, 2018
BackgroundAcute lung injury (ALI) is characterized by suppressed fibrinolytic activity in bronchoalveolar lavage fluid (BALF) attributed to elevated plasminogen activator inhibitor-1 (PAI-1).
Cong Liu, Yana Ma, Zhenlei Su, Runzhen Zhao, Xiaoli Zhao, Hong-Guang Nie, Ping Xu, Lili Zhu, Mo Zhang, Xiumin Li, Xiaoju Zhang, Michael A. Matthay, Hong-Long Ji   +12 more
doaj   +3 more sources

Enhanced Production of Fibrinolytic Enzyme from Pseudomonas aeruginosa by Optimization Media Components [PDF]

Journal of Applied Sciences and Nanotechnology, 2021
Fibrinolytic enzyme is factor that lysis fibrin clots. This fibrinolytic factor has prospective use to treat cardiovascular diseases, such as stroke and heart attack. Cardiovascular diseases attracted worldwide attention for their elevation morbidity and
Bilal Jasim, Entesar Ali
doaj   +1 more source

Marine Microbial Fibrinolytic Enzymes: An Overview of Source, Production, Biochemical Properties and Thrombolytic Activity

Marine Drugs, 2022
Cardiovascular diseases (CVDs) have emerged as a major threat to global health resulting in a decrease in life expectancy with respect to humans. Thrombosis is one of the foremost causes of CVDs, and it is characterized by the unwanted formation of ...
Noora Barzkar, Saeid Tamadoni Jahromi, Fabio Vianello   +2 more
doaj   +1 more source

Plant-Derived Compounds and Extracts as Modulators of Plasmin Activity—A Review

Molecules, 2023
Functionality of the fibrinolytic system is based on activity of its central enzyme, plasmin, responsible for the removal of fibrin clots. Besides the hemostasis, fibrinolytic proteins are also involved in many other physiological and pathological ...
Joanna Kolodziejczyk-Czepas, Jan Czepas
doaj   +1 more source

Fibrinolytic Protease Activity of Crude Enzyme from Fermented Sunflower (Helianthus annuus) and Common Bean (Phaseolus vulgaris) seeds by Rhizopus microsporus var. oligosporus FNCC 6010 in Solid State Fermentation

Borneo Journal of Pharmacy, 2023
In the entire world, cardiovascular diseases (CVDs) are the main cause of death. For the treatment of CVDs, microbial fibrinolytic enzymes are highly regarded as novel therapeutic candidates.
Rebhika Lusiana, Achmad Toto Poernomo, Achmad Syahrani   +2 more
doaj   +1 more source