Urokinase for thrombolysis in patients with acute ischemic stroke: rationale and design of a phase I dose-escalation study [PDF]
Frontiers in NeurologyBackgroundPrevious evidence supports the efficacy and safety of intravenous urokinase thrombolysis in acute ischemic stroke (AIS), with additional advantages in terms of cost-effectiveness.
Shengjun Wang +6 more
doaj +2 more sources
Case Report: Early management and successful thrombolysis in two cases of high-risk pulmonary embolism [PDF]
Frontiers in MedicineThrough analyzing two cases of acute fatal pulmonary embolism, we emphasize the critical importance of early diagnosis, timely risk assessment, and precise thrombolytic therapy, particularly for hemodynamically unstable patients.
Yan Zhang +6 more
doaj +2 more sources
Low-dose urokinase thrombolysis combined with papaverine for central retinal artery occlusion: a preliminary exploration of efficacy and safety [PDF]
Frontiers in NeurologyObjectiveTo investigate the efficacy and safety of low-dose urokinase combined with papaverin administered via superselective ophthalmic artery thrombolysis in patients with non-arteritic central retinal artery occlusion (CRAO).MethodsA retrospective ...
Hongyan Sun +10 more
doaj +2 more sources
Free flap salvage via direct urokinase injection into thrombosed veins: a case report [PDF]
Case Reports in Plastic Surgery & Hand SurgeryIntraoperative use of urokinase is a recognized method for salvaging compromised free flaps. However, protocols for dosage and administration vary, and no consensus exists regarding the optimal technique.
Masanobu Hayashi +5 more
doaj +2 more sources
Fibrinolysis with Lower Dose Urokinase in Patients with Complicated Parapneumonic Effusion [PDF]
Tuberculosis and Respiratory Diseases, 2021 Background Intrapleural urokinase is one of the most widely used fibrinolytic agents in the treatment of complicated parapneumonic effusion (CPPE). However, little research has been performed on the optimal urokinase dosage.
Seul Lee +8 more
doaj +1 more source
Efficacy and safety of catheter-directed thrombolytic therapy of alteplase and urokinase for the treatment of deep vein thrombosis: a Meta-analysis [PDF]
Yixue xinzhi zazhi, 2023 Objective To systematically review the effectiveness and safety of cathe-ter-directed thrombolytic therapy (CDT) using alteplase and urokinase in the treatment of deep vein thrombosis (DVT) in the lower extremities.Method PubMed, The Cochrane Library ...
Hong-Yan LI +6 more
doaj +1 more source
Neurologia Medico-Chirurgica, 2022 Delayed cerebral vasospasms after subarachnoid hemorrhage (SAH) are a risk factor for poor prognosis after successful treatment of ruptured intracranial aneurysms.
Arata NAGAI +5 more
doaj +1 more source
Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface [PDF]
The Ukrainian Biochemical Journal, 2019 Platelets play a key role in hemostasis as cofactors of thrombin generation, fibrin polymerization centers, and initiators of clot retraction, while their ability to modulate clot dissolution remains less understood.
T. Grinenko +4 more
doaj +1 more source
Frontiers in Neurology, 2021 Background: Intravenous thrombolysis with alteplase benefits eligible patients with acute ischemic stroke. However, in some countries such as China, alteplase may be too expensive for low-income patients, and also for regions with low economic ...
Rongrong Zhang +11 more
doaj +1 more source