Sodium bicarbonate combined with urokinase for the prevention and management of hemodialysis central venous catheter dysfunction [PDF]
Frontiers in PharmacologyBackgroundCentral venous catheter (CVC) dysfunction remains a common problem in maintenance hemodialysis and may impair prescribed blood flow and dialysis adequacy.
Lin Lin +5 more
doaj +2 more sources
Influence of Endoplasmic Reticulum Stress on Urokinase Plasminogen Activation [PDF]
BiomoleculesThe urokinase plasminogen activator or urokinase is a highly specific extracellular protease involved in numerous physiological and pathological processes.
Diana Culej Bošnjak +4 more
doaj +2 more sources
Urokinase for thrombolysis in patients with acute ischemic stroke: rationale and design of a phase I dose-escalation study [PDF]
Frontiers in NeurologyBackgroundPrevious evidence supports the efficacy and safety of intravenous urokinase thrombolysis in acute ischemic stroke (AIS), with additional advantages in terms of cost-effectiveness.
Shengjun Wang +6 more
doaj +2 more sources
Case Report: Early management and successful thrombolysis in two cases of high-risk pulmonary embolism [PDF]
Frontiers in MedicineThrough analyzing two cases of acute fatal pulmonary embolism, we emphasize the critical importance of early diagnosis, timely risk assessment, and precise thrombolytic therapy, particularly for hemodynamically unstable patients.
Yan Zhang +6 more
doaj +2 more sources
Intrapleural Fibrinolytic Therapy in the Management of Pediatric Pleural Empyema: A Narrative Review [PDF]
PharmaceuticalsBackground: Pediatric pleural empyema is a major complication of community-acquired pneumonia and remains associated with substantial morbidity despite advances in vaccination, antimicrobial therapy, and supportive care. Intrapleural fibrinolytic therapy
Susanna Esposito +3 more
doaj +2 more sources
AP1 Transcription Factor in the Regulation of the Urokinase Plasminogen Activation System [PDF]
BiomoleculesUrokinase plasminogen activation system regulates the activation of plasminogen to produce the ubiquitous extracellular protease plasmin. It is involved in different physiological and pathophysiological processes, which involve tissue reorganization ...
Petra Korać +2 more
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Urokinase redux: route, compartment, access, and pharmacological evolution from native urokinase to recombinant prourokinase [PDF]
Frontiers in Cardiovascular MedicineUrokinase is often regarded as an older thrombolytic displaced by fibrin-selective agents in reperfusion medicine. Yet its decline has been uneven. This mini-review reframes its contemporary role through three determinants: route, compartment, and access.
Xuxu Xu +3 more
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Fibrinolysis with Lower Dose Urokinase in Patients with Complicated Parapneumonic Effusion [PDF]
Tuberculosis and Respiratory Diseases, 2021 Background Intrapleural urokinase is one of the most widely used fibrinolytic agents in the treatment of complicated parapneumonic effusion (CPPE). However, little research has been performed on the optimal urokinase dosage.
Seul Lee +8 more
doaj +1 more source
Efficacy and safety of catheter-directed thrombolytic therapy of alteplase and urokinase for the treatment of deep vein thrombosis: a Meta-analysis [PDF]
Yixue xinzhi zazhi, 2023 Objective To systematically review the effectiveness and safety of cathe-ter-directed thrombolytic therapy (CDT) using alteplase and urokinase in the treatment of deep vein thrombosis (DVT) in the lower extremities.Method PubMed, The Cochrane Library ...
Hong-Yan LI +6 more
doaj +1 more source
Neurologia Medico-Chirurgica, 2022 Delayed cerebral vasospasms after subarachnoid hemorrhage (SAH) are a risk factor for poor prognosis after successful treatment of ruptured intracranial aneurysms.
Arata NAGAI +5 more
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