Results 131 to 140 of about 182,452 (306)

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

再灌注治疗的神经影像学评估 Neuroimaging Evaluation of Reperfusion Therapy

Zhongguo cuzhong zazhi
目前，以缺血半暗带为靶点的再灌注治疗是急性缺血性卒中的首选治疗措施。缺血半暗带的神经影像学评估方法不断更新，为组织窗指导再灌注治疗提供了更多依据。本文对缺血半暗带理论50年来的重要进展进行梳理，重点综述了现有的缺血半暗带神经影像学评估方法（如目前被广泛使用的缺血低灌注-梗死核心或临床症状-梗死核心错配、新兴的多时相CTA及ASL等），并对目前市场上5款主流影像自动后处理软件进行对比，以期为临床再灌注诊疗工作提供参考。 Abstract: Currently, reperfusion therapy
郝曼均1，王利圆1，熊云云1，2，3 (HAO Manjun1, WANG Liyuan1, XIONG Yunyun1,2,3 )
doaj   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Clinical, Laboratory and Instrumental Characteristics of Myocardial Infarction in Young Patients Depending on the Prevalence of Coronary Atherosclerosis

Medicina
Background and Objectives: To study the clinical/anamnestic, laboratory and instrumental characteristics, as well as the tactics of treatment, of myocardial infarction (MI) in young patients, depending on the number of affected coronary arteries (CAs ...
Gleb Vladimirovich Nozhov, Kristina Gennadievna Pereverzeva, Sergey Sergeevich Zagorodniy, Sergey Stepanovich Yakushin, Elizaveta Sergeevna Platonova, Angelina Vladimirovna Sermavbrina, German Maksimovich Popov, Elizaveta Romanovna Martynova   +7 more
doaj   +1 more source

Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries [PDF]

, 2017
Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients ...
Agladze, Vaja, Alexopoulos, Dimitrios, Alhabib, Khalid F., Almeida, Manuel, Antoniades, Loizos, Antov, S., Babic, Z., Becker, David, Birkhead, John, Bjornsdottir, Thora K., Bovenzi, Francesco, Cavanagh, Brendan, Christodulides, Theodoros, Claeys, Marc J., Clemmensen, Peter, Cremonesi, Alberto, D'Angeli, Cinzia, Daly, Kieran, De Boer, Menko-Jan, De Luca, Leonardo, Deleanu, Dan, Di Mario, Carlo, Dobric, Milan, Dudek, Dariusz, Erglis, Andrejs, Erne, Paul, Ertas, Gokhan, Fajadet, Jean, Galatius, Søren, Georgiou, Panagiota, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hajric, R., Hansen, Kim Wadt, Hricak, V., Huber, Kurt, James, Stefan, Janota, Tomáš, Jansky, Petr, Jennings, Siobhan, Jorgova, Julia, Kaifoszova, Zuzana, Kajander, Olli, Kala, Petr, Kallikazaros, Ioannis, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kervan, Umit, Kiss, Robert Gabor, Koch, Karel T., Kornowski, Ran, Kovař, F., Kozan, Omer, Kristensen, Steen D., Kurray, P., Laut, Kristina G., Legrand, V., Ludman, Peter F., Maca, Aija, Markota, D., Matetzky, Shlomi, Merkely, Béla, Milicic, Davor, Mimoso, Jorge, Mühlberger, Volker, Müller, Alfred, Najafov, Ruslan, Najafov, Ruslan, Narbute, Inga, Nedeljkovic, Milan, Nicolaides, Evagoras, Nicolini, Francesca A., Nikolic Heitzler, V., Noč, Marko, Ostojic, Miodrag, Papaioannou, Georgios, Peral, Vincente, Pereira, Ernesto, Pereira, Hélder, Petrov, Ivo, Radovanovic, Dragana, Regueiro, Ander, Rickli, Hans, Romppanen, Hannu, Rustige, Jörg, Sabaté, Manel, Shal, Ahmed El, Skuladottir, Frida Bjork, Sobhy, Mohamed, Sobhy, Mohamed, Sokolov, Maxim, Sokolov, Yuriy, Spuzic, M., Srdic, S., Stasek, Josef, Studencan, Martin, Sørensen, Rikke, Tatu, Gabriel, Terkelsen, Christian Juhl, Terzic, Ibrahim, Tresserras, Ricard, Twomey, Kathleen, Ungi, Imre, Velchev, Vassil, Vinereanu, Dragos, Vukcevic, Vladan, Wahler, Steffen, Widimsky, Petr, Wijns, William, Windecker, Stephan, Zakke, IIja   +113 more
core  

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

急性缺血性卒中患者再灌注治疗后血压变异性与功能预后的相关性研究（Correlation between Blood Pressure Variability and Functional Outcomes in Patients with Acute Ischemic Stroke after Reperfusion Therapy）

Zhongguo cuzhong zazhi
目的 评估急性缺血性卒中（acute ischemic stroke，AIS）患者再灌注治疗后全时段（急性期、亚急性期及家庭血压监测期）的血压变异性（blood pressure variability，BPV）与功能预后的相关性。 方法 前瞻性连续纳入2022年7月—2023年10月北京市大兴区人民医院神经内科收治的接受再灌注治疗[静脉溶栓和（或）血管内治疗]的AIS患者。收集患者的人口学信息、既往病史、发病前mRS评分、入院NIHSS评分、发病至到院时间及入院后治疗信息等资料 ...
尹梦鑫，段春苗，杨海华（YIN Mengxin, DUAN Chunmiao, YANG Haihua）
doaj   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source