Results 151 to 160 of about 4,697,552 (378)
Chapter 59 Approaches to neuroprotective and reperfusion injury therapy
, 2008 Publisher Summary This chapter focuses on the advances of neuroprotection related to cerebral ischemia/reperfusion injury. The unsuccessful pursuit of pharmacological protection is emphasized. This highlights the importance of controlling the physiological parameters (that is, blood flow, body temperature, and glucose levels) when carrying out ...
Papadakis, M, Buchan, A
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Journal of Nobel Medical College, 2015 Background: Studies have shown that women are less likely to receive reperfusion therapy and have higher inhospital death in ST Elevation myocardial infarction(STEMI) as compared to men.
Hemant Shrestha +5 more
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Systolic left ventricular function after reperfusion therapy for acute myocardial infarction. Analysis of determinants of improvement. The TAMI Study Group. [PDF]
, 1993 J. Kevin Harrison +9 more
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Oxidative Medicine and Cellular Longevity, 2017 Prompt coronary reperfusion is the gold standard for minimizing injury following acute myocardial infarction. Rapamycin, mammalian target of Rapamycin (mTOR) inhibitor, exerts preconditioning-like cardioprotective effects against ischemia/reperfusion (I ...
Scott M. Filippone +7 more
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Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition
Advanced Science, EarlyView.Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu +12 more
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再灌注治疗的神经影像学评估 Neuroimaging Evaluation of Reperfusion Therapy
Zhongguo cuzhong zazhi目前，以缺血半暗带为靶点的再灌注治疗是急性缺血性卒中的首选治疗措施。缺血半暗带的神经影像学评估方法不断更新，为组织窗指导再灌注治疗提供了更多依据。本文对缺血半暗带理论50年来的重要进展进行梳理，重点综述了现有的缺血半暗带神经影像学评估方法（如目前被广泛使用的缺血低灌注-梗死核心或临床症状-梗死核心错配、新兴的多时相CTA及ASL等），并对目前市场上5款主流影像自动后处理软件进行对比，以期为临床再灌注诊疗工作提供参考。 Abstract: Currently, reperfusion therapy
郝曼均1，王利圆1，熊云云1，2，3 (HAO Manjun1, WANG Liyuan1, XIONG Yunyun1,2,3 )
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Advanced Science, EarlyView.This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong +3 more
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Acta Medica IndonesianaBackground: Reperfusion serves as a mainstay therapy in almost all ischemic vascular diseases (IVD), but reperfusion may enhance cell damage after an ischemic period time.
Dono Antono +2 more
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Zhongguo cuzhong zazhi急性缺血性卒中是一种严重威胁人类健康的疾病，其中大动脉粥样硬化性卒中症状更重，预后更差，再灌注治疗可有效改善这类患者的功能预后。近年来再灌注治疗技术发展迅速，但也面临一些挑战，如治疗时间窗内患者比例低、再灌注损伤、出血转化等。要解决这些问题，需要从多个层面采取对策，如优化急救流程、革新操作技术、加强损伤防护等。本文对大动脉粥样硬化性缺血性卒中再灌注治疗面临的挑战和对策进行了初步讨论。 Abstract: Acute ischemic stroke is a serious disease that ...
符鹏程1*，曹黎明2*，朱佳倩1，3，赵桂玉1，徐格林1（*第一作者）(FU Pengcheng1*, CAO Liming2*, ZHU Jiaqian1,3, ZHAO Guiyu1, XU Gelin1 (*contributed equally). )
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Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
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