Results 331 to 340 of about 4,697,552 (378)

Astragaloside IV Alleviates Ulcerative Colitis Progression by Inhibiting WDR5‐Mediated ENO1 H3K4me3 Modification

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ulcerative colitis (UC) has become a prevalent global health concern. This study scrutinized the influence of Astragaloside IV (ASI) on DSS‐induced UC, with particular emphasis on the role of WDR5 in mediating ENO1 expression. The therapeutic efficacy of ASI was assessed in a mouse model of UC by evaluating disease activity index, pathology ...
Su‐Xiao Wu, Zi‐Lan Chen, Xiao‐Hong Wang, Jie Gu   +3 more
wiley   +1 more source

Ginsenoside Rg1 Restores Sirt2/Foxo1 Expression and Alleviates Autism‐Like Behaviors in a Valproic Acid Induced Male Mouse Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated whether Ginsenoside Rg1 (Rg1) alleviates autism‐like behaviors in mice prenatally exposed to valproic acid (VPA) via Sirt2/Foxo1 signaling. Pregnant C57BL/6J mice received a single intraperitoneal injection of VPA (600 mg/kg) on embryonic Day 12.5 to establish an autism model.
Fan‐Xu Song, Qing‐Wei Wu, Wei Pan, Li‐Jun Liu, Xin Li, Xue Zhou, Zong‐Yao Yu, Xin Ning, Lan‐Min Guo   +8 more
wiley   +1 more source

Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart

, 2013
Xi‐Ming Yang, Lin Cui, Ahmad Alhammouri, James M. Downey, Michael V. Cohen   +4 more
openalex   +2 more sources

Initial experience of cardiac T1ρ mapping at 0.55 T: Continuous wave versus adiabatic spin‐lock preparation pulses

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose To propose and validate a cardiac T1ρ mapping sequence at 0.55 T comparing continuous‐wave and adiabatic spin‐lock (SL) preparation pulses. Methods The proposed 2D sequence acquires four single‐shot balanced SSFP readout images with differing contrasts in a single breath‐hold.
Dongyue Si, Michael G. Crabb, Simon J. Littlewood, Karl P. Kunze, Juliet Varghese, Katherine Binzel, Mahmood Khan, Orlando P. Simonetti, Claudia Prieto, René M. Botnar   +9 more
wiley   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Micro‐ and nanomotors in biomedical applications

Responsive Materials, EarlyView.
Micro‐ and nanomotors (MNMs), as autonomous devices converting chemical or external energy into mechanical propulsion, have emerged as transformative drug delivery platforms in biomedicine. This review systematically outlines the design principles governing MNMs' propulsion and operation, highlights the applications of MNMs in disease treatment, and ...
Xiangyu Meng, Yuqi Tang, Quan Li
wiley   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, EarlyView.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Myocardial Infarction with ST Elevation and Reperfusion Therapy in Brazil: Data from the ACCEPT Registry. [PDF]

Arq Bras Cardiol
Ritt LEF, Silva PGMBE, Darzé ES, Santos RHN, de Oliveira QB, Berwanger O, Mattos LAPE, Dos Santos ES, Souza ACS, Cavalcante MA, de Andrade PB, Neuenschwander FC, Vargas Filho H, Guimarães JI, de Andrade JP, de Paola AAV, Malachias MVB, Précoma DB, Bacal F, Dutra OP.   +19 more
europepmc   +1 more source