Results 61 to 70 of about 185,231 (352)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy

Journal of Stroke and Cerebrovascular Diseases
This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy ...
Marc Ribó, Jacek Staszewski, Steven R. Zeiler, Sławomir Michalak, Ahmed El Bassiouny, Fernando Gongora-Rivera, Zdravka Poljakovic, Dina R Khasanova, Mikhail N Kalinin, Aurauma Chutinet, Roni Eichel, Klaudyna Kojder, Marissa Ong, Marina Roje Bedeković, Chien-Hung Chang, Minwoo Lee, Peter Quitasol, Alexander Tsiskaridse, Natan M Bornstein   +18 more
doaj   +1 more source

Peculiarities and recommendations of acute stroke treatment during the COVID-19 pandemic

Neurologijos seminarai, 2020
The global COVID-19 pandemic poses enormous challenges to healthcare systems and has a major impact on the treatment and care of stroke patients. In the article, the authors review the issues of acute stroke diagnosis, treatment, and prevention during ...
A. Vilionskis , R. Masiliūnas , A. Ekkert , D. Jatužis   +3 more
doaj   +1 more source

Current issues in reperfusion therapy

The American Journal of Cardiology, 1998
With the establishment of thrombosis as the cause of myocardial infarction, the pivotal role of thrombolytics and primary angioplasty has evolved. Large randomized trials with innovative methodologies have examined the role of these reperfusion therapies in the management of acute coronary syndromes. Intravenous thrombolytic therapy decreases mortality
openaire   +2 more sources

Adjunctive therapy after reperfusion therapy in acute myocardial infarction [PDF]

Clinical Cardiology, 1998
AbstractThe current era has witnessed dramatic improvement in the treatment of acute myocardial infarction, due in large part to the more widespread use of thrombolytic therapy aimed at quickly restoring perfusion in the infarct‐related artery. This review addresses the role of adjunctive pharmacologic therapy in the thrombolytic era, recognizing that ...
D L, Dries, A J, Solomon, B J, Gersh
openaire   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke

Brain Circulation
Acute ischemic stroke (AIS) remains to be a challenging cerebrovascular disease. The mainstay of AIS management is endovascular reperfusion therapy, including thrombectomy and thrombolysis.
Ahmed Elmadhoun, Hongrui Wang, Yuchuan Ding   +2 more
doaj   +1 more source

10-Point CT-ASPECTS-based reperfusion therapy for unknown onset stroke

Journal of the Formosan Medical Association, 2018
Under the time-based criteria, patients with unknown onset stroke (UOS) are ineligible for reperfusion therapies. However, previous studies suggest that some patients with UOS may benefit from reperfusion.
Che-Cheng Chang, Hsu-Ling Yeh, Chen-Yu Hsiao, Li-Ming Lien   +3 more
doaj   +1 more source

Assessing the effectiveness of primary angioplasty compared with thrombolysis and its relationship to time delay: a Bayesian evidence synthesis [PDF]

, 2007
Background: Meta-analyses of trials have shown greater benefits from angioplasty than thrombolysis after an acute myocardial infarction, but the time delay in initiating angioplasty needs to be considered.
Abrams, Keith R., Asseburg, Christian, de Belder, Mark, Fenwick, Elisabeth, Palmer, Stephen, Sculpher, Mark, Vergel, Yolanda Bravo   +6 more
core   +4 more sources

Reperfusion Therapies for Wake-Up Stroke [PDF]

Stroke, 2014
Patients who present with stroke symptoms on awakening, often referred to as wake-up stroke (WUS), account for ≈25% of acute ischemic strokes.1 In this group, onset time is unknown and usually defined conservatively as time last seen well (LSW) before sleeping.2,3 Onset time is important because benefit from intravenous thrombolysis is time dependent ...
Buck, Deborah, Shaw, Lisa C., Price, Christopher I., Ford, Gary A.   +3 more
openaire   +2 more sources