Results 51 to 60 of about 182,452 (306)

The meaning of different forms of structural myocardial injury, immune response and timing of infarct necrosis and cardiac repair [PDF]

, 2015
Although a decline in the all-cause and cardiac mortality rates following myocardial infarction (MI) during the past 3 decades has been reported, MI is a major cause of death and disability worldwide.
Bello, S, Fineschi, Vittorio, Neri, M, Pomara, C, Riezzo, I, Turillazzi, E   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Peculiarities and recommendations of acute stroke treatment during the COVID-19 pandemic

Neurologijos seminarai, 2020
The global COVID-19 pandemic poses enormous challenges to healthcare systems and has a major impact on the treatment and care of stroke patients. In the article, the authors review the issues of acute stroke diagnosis, treatment, and prevention during ...
A. Vilionskis , R. Masiliūnas , A. Ekkert , D. Jatužis   +3 more
doaj   +1 more source

Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling [PDF]

, 2001
The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Jonassen, A.K., Mjøs, O.D., Sack, M.N., Yellon, D.M.   +3 more
core  

Inequalities in reperfusion therapy for STEMI [PDF]

European Heart Journal - Quality of Care and Clinical Outcomes, 2016
This editorial refers to “Reperfusion therapy for ST-elevation acute myocardial infarction in Eastern Europe: the ISACS-TC registry”, by E. Cenko et al ., on page 45. Reperfusion therapy, either by intravenous fibrinolysis or percutaneous coronary intervention (PCI), is the cornerstone of the management of ST-elevation myocardial infarction (STEMI).1
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy

Journal of Stroke and Cerebrovascular Diseases
This article provides perspectives on the use of Cerebrolysin as an adjunct treatment to reperfusion therapy in acute ischemic stroke (AIS). In the evolving landscape of AIS reperfusion therapy, we hypothesize that adjunctive cerebroprotective therapy ...
Marc Ribó, Jacek Staszewski, Steven R. Zeiler, Sławomir Michalak, Ahmed El Bassiouny, Fernando Gongora-Rivera, Zdravka Poljakovic, Dina R Khasanova, Mikhail N Kalinin, Aurauma Chutinet, Roni Eichel, Klaudyna Kojder, Marissa Ong, Marina Roje Bedeković, Chien-Hung Chang, Minwoo Lee, Peter Quitasol, Alexander Tsiskaridse, Natan M Bornstein   +18 more
doaj   +1 more source

10-Point CT-ASPECTS-based reperfusion therapy for unknown onset stroke

Journal of the Formosan Medical Association, 2018
Under the time-based criteria, patients with unknown onset stroke (UOS) are ineligible for reperfusion therapies. However, previous studies suggest that some patients with UOS may benefit from reperfusion.
Che-Cheng Chang, Hsu-Ling Yeh, Chen-Yu Hsiao, Li-Ming Lien   +3 more
doaj   +1 more source

Total Thiols and MDA Levels in Patients with Acute Myocardial Infarction Before and After Reperfusion Therapy [PDF]

, 2010
Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction ...
Babu, Suresh, Mungli, Prakash, Shetty, Jeevan K   +2 more
core   +1 more source

Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]

, 2015
Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P., Hammers, David W., Hsieh, Pei-Ling, Merscham-Banda, Melissa, Pham, Chantal B., Rybalko, Viktoriya Y., Suggs, Laura J.   +6 more
core   +1 more source