Results 71 to 80 of about 4,697,552 (378)

Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical

Stroke and Vascular Neurology
Stroke is the second-leading cause of death and the leading cause of disability in much of the world. In particular, China faces the greatest challenge from stroke, since the population is aged quickly.
Mingyu Chen, Dongya Zhu, Xiumei Xu
doaj   +1 more source

Relation between Initial QRS Duration with Myocardial Reperfusion after Primary PCI

Majalah Kardiologi Indonesia, 2013
Background.Reperfusion therapy in acute myocardial infarction aims at early and sustained reperfusion of the myocardium at risk. However, even when TIMI flow 3 is achieved, some patients have less optimal reperfusion at myocardial tissue level.
doaj   +1 more source

Outcome of very elderly (octogenarians) patients with coronary artery disease, all diagnosed by coronary angiography [PDF]

, 2017
Background: Women with ischemic heart disease (IHD) typically present less severe coronary artery atherosclerosis. Despite that, as compared with men, women maintain a worse outcome.
Arrivi, Alessio, Basili, Stefania, Marcello Dominici and Enrico Mangieri,, Nicola, Viceconte, Raparelli, Valeria, Sperduti, Nicolo', Tanzilli, Alessandra, Tanzilli, Gaetano, Truscelli, Giovanni   +8 more
core   +1 more source

A revolution in stroke therapy: reperfusion therapy effective even if late [PDF]

European Heart Journal Supplements, 2020
Abstract Arterial recanalization procedures after ischaemic stroke, are now well-established treatments, within 5 h for systemic thrombolysis, and 6 h for the endovascular treatment. Ischaemic stroke with uncertain time of symptoms onset, account for 14–27% of the cases, the vast majority of which occur just after waking up, thus it is ...
Toni, Danilo, Risitano, Angela, Gentile, Luana   +2 more
openaire   +3 more sources

Animal models of ischaemic stroke and characterisation of the ischaemic penumbra [PDF]

, 2018
Over the past forty years, animal models of focal cerebral ischaemia have allowed us to identify the critical cerebral blood flow thresholds responsible for irreversible cell death, electrical failure, inhibition of protein synthesis, energy depletion ...
Arroja, Mariana M., Macrae, I. Mhairi, McCabe, Christopher, Reid, Emma   +3 more
core   +1 more source

The Heidelberg Bleeding Classification: Classification of Bleeding Events After Ischemic Stroke and Reperfusion Therapy.

Stroke, 2015
Intracranial hemorrhage is an important safety end point in clinical trials.1–6 Yet, not each intracranial hemorrhage detected by computed tomography (CT) or magnetic resonance imaging (MRI) worsens neurological symptoms and impairs outcomes ...
R. von Kummer, J. Broderick, B. Campbell, A. Demchuk, M. Goyal, M. Hill, K. Treurniet, C. Majoie, H. Marquering, M. Mazya, L. San Román, J. Saver, D. Strbian, W. Whiteley, W. Hacke   +14 more
semanticscholar   +1 more source

Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling [PDF]

, 2001
The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Jonassen, A.K., Mjøs, O.D., Sack, M.N., Yellon, D.M.   +3 more
core  

Hyperoxia Induced Alteration of Chromatin Structure in Human Bone Marrow Derived Primary Mesenchymal Stromal Cells

Advanced Biology, EarlyView.
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe, Samantha Kaonis, Natalie Calahan, Neda Kabi, Soham Ghosh   +4 more
wiley   +1 more source

Cardioprotective effects of shock wave therapy: A cardiac magnetic resonance imaging study on acute ischemia-reperfusion injury

Frontiers in Cardiovascular Medicine, 2023
IntroductionCardioprotection strategies remain a new frontier in treating acute myocardial infarction (AMI), aiming at further protect the myocardium from the ischemia-reperfusion damage.
Lorena Petrusca, Pierre Croisille, Pierre Croisille, Lionel Augeul, Michel Ovize, Michel Ovize, Nathan Mewton, Nathan Mewton, Magalie Viallon, Magalie Viallon   +9 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources