Results 271 to 280 of about 705,796 (337)

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

ChemBioChem, EarlyView.
This study unveils a novel synthetic platform by solid‐phase peptide synthesis for generating FUBI‐based chemical tools to investigate FUBIylation, a poorly understood ubiquitin‐like signaling process linked to cancer. By employing these innovative probes, we uncover novel FUBI interactors, paving the way for transformative insights into FUBI biology ...
Francesca D’Amico, Cami M. P. Talavera Ormeño, Shivanganie Poeran, Jimmy Akkermans, Rayman T. N. Tjokrodirijo, Bharath Sampadi, Peter van Veelen, Aysegul Sapmaz, Monique P. C. Mulder   +8 more
wiley   +1 more source

T-cell receptor dynamics in digestive system cancers: a multi-layer machine learning approach for tumor diagnosis and staging. [PDF]

Front Immunol
Yuan C, Wang B, Wang H, Wang F, Li X, Zhen Y.   +5 more
europepmc   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, Accepted Article.
Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing protein translocation to the PM is an effective strategy for dissecting cell signaling networks
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

Front Immunol
Ryback AA, Cowan GJM.
europepmc   +1 more source

Thioxanthone: A Benchmark Photocatalyst for Organic Synthesis

ChemCatChem, EarlyView.
Thioxanthone is a highly versatile and effective organocatalyst for photochemical applications, with its low‐toxicity, metal‐free structure driving growing interest in sustainable photocatalysis. Building on our previous 2021 review, this update covers advances from 2021–2025 in thioxanthone‐based synthetic organic photochemistry – excluding ...
Vera P. Demertzidou, Elpida Skolia, Christoforos G. Kokotos   +2 more
wiley   +1 more source

Selective expression of <i>Pneumocystis</i> antigens in different patients during a suspected outbreak of <i>Pneumocystis</i> pneumonia. [PDF]

mBio
Meier CS, Pagni M, Richard S, Mühlethaler K, Hauser PM.   +4 more
europepmc   +1 more source

Constraint and innovation in the traditional fiddle repertoire of Cape Breton [PDF]

, 2016
Sommers Smith, Sally K.
core  

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

Chemistry – A European Journal, EarlyView.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker, Jan‐Simon Behnke, Leonhard H. Urner   +2 more
wiley   +1 more source

Gradual changes within long-lived influenza virus-specific CD8⁺ T cells are associated with the loss of public TCR clonotypes in older adults. [PDF]

EBioMedicine
van de Sandt CE, McQuilten HA, Aban M, Nguyen THO, Valkenburg SA, Grant EJ, Sant S, Rossjohn J, Gras S, Crowe J, Kedzierska K.   +10 more
europepmc   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source