Results 71 to 80 of about 286,193 (316)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Analysis and Design of A PMQR-Type Repetitive Control Scheme for Grid-Connected H6 Inverters
Applied Sciences, 2019 There exist several challenges in the implementation of proportional multiple quasi-resonant (PMQR) control strategies in single-phase grid-connected H6 inverters, such as high computational costs and design complexity. To overcome these challenges, this
Xiaohui Yang +3 more
doaj +1 more source
Learning-Based Repetitive Control of a Bowden-Cable-Actuated Exoskeleton with Frictional Hysteresis. [PDF]
Micromachines (Basel), 2022 Shi Y +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Preview repetitive control for polytopic nonlinear discrete-time systems. [PDF]
Sci Prog, 2022 Li L, Jia C.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
[Adaptive repetitive control of wrist tremor suppression based on functional electrical stimulation]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2023 Zhang Z, Liu Y, Chu B, Huo B, Owens DH.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Robust Guaranteed-Cost Preview Repetitive Control for Polytopic Uncertain Discrete-Time Systems
Algorithms, 2019 In this paper, a robust guaranteed-cost preview repetitive controller is proposed for a class of polytopic uncertain discrete-time systems. In order to improve the tracking performance, a repetitive controller, combined with preview compensator, is ...
Yong-Hong Lan +2 more
doaj +1 more source