Results 131 to 140 of about 152,959 (253)

Redundancy, noise, and plasticity: repetitive DNA as an epigenetic intelligence backbone of inflammatory regulation. [PDF]

Environ Epigenet
Bollati V, Biganzoli E.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Repetitive DNA Dynamics, Phylogenetic Relationships and Divergence Times in Andean <i>Ctenomys</i> (Rodentia: Ctenomyidae). [PDF]

Biology (Basel)
Vargas RA, Haro RE, Di-Nizo CB, Suárez-Villota EY.   +3 more
europepmc   +1 more source

In-Depth Satellitome Analyses of 37 Drosophila Species Illuminate Repetitive DNA Evolution in the Drosophila Genus. [PDF]

Genome Biol Evol, 2022
de Lima LG, Ruiz-Ruano FJ.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Genomic characterization of repetitive DNA and transposable elements in Dyckia (Pitcairnioideae) species. [PDF]

BMC Res Notes
Silva Rabelo-Araujo JVD, Francisconi AF, da Costa ZP, Garcia CB, de Castro Ribeiro OB, Anastacio ACSA, Zucchi MI.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma. [PDF]

Front Cell Dev Biol
Zhang M, Dong S, Rao W, Mei S, Hu G, Liu L, Wang Z, Tang J.   +7 more
europepmc   +1 more source

Characterization of Repetitive DNA in Saccharum officinarum and Saccharum spontaneum by Genome Sequencing and Cytological Assays. [PDF]

Front Plant Sci, 2022
Wang K, Xiang D, Xia K, Sun B, Khurshid H, Esh AMH, Zhang H.   +6 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source