Results 21 to 30 of about 151,453 (283)
Perm-seq: Mapping Protein-DNA Interactions in Segmental Duplication and Highly Repetitive Regions of Genomes with Prior-Enhanced Read Mapping. [PDF]
PLoS Computational Biology, 2015 Segmental duplications and other highly repetitive regions of genomes contribute significantly to cells' regulatory programs. Advancements in next generation sequencing enabled genome-wide profiling of protein-DNA interactions by chromatin ...
Xin Zeng +6 more
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Repetitive Sequences in Plant Nuclear DNA: Types, Distribution, Evolution and Function
Genomics, Proteomics & Bioinformatics, 2014 Repetitive DNA sequences are a major component of eukaryotic genomes and may account for up to 90% of the genome size. They can be divided into minisatellite, microsatellite and satellite sequences.
Shweta Mehrotra, Vinod Goyal
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BMC Genomics, 2008 Background The majority of human non-protein-coding DNA is made up of repetitive sequences, mainly transposable elements (TEs). It is becoming increasingly apparent that many of these repetitive DNA sequence elements encode gene regulatory functions ...
McDonald John F +4 more
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Algorithms for Molecular Biology, 2021 Background Repetitive elements contribute a large part of eukaryotic genomes. For example, about 40 to 50% of human, mouse and rat genomes are repetitive. So identifying and classifying repeats is an important step in genome annotation.
Fabian Hausmann, Stefan Kurtz
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Directed PCR-free engineering of highly repetitive DNA sequences
BMC Biotechnology, 2011 Background Highly repetitive nucleotide sequences are commonly found in nature e.g. in telomeres, microsatellite DNA, polyadenine (poly(A)) tails of eukaryotic messenger RNA as well as in several inherited human disorders linked to trinucleotide repeat ...
Preissler Steffen +3 more
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The case for not masking away repetitive DNA
Mobile DNA, 2018 In the course of analyzing whole-genome data, it is common practice to mask or filter out repetitive regions of a genome, such as transposable elements and endogenous retroviruses, in order to focus only on genes and thus simplify the results.
R. Keith Slotkin
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BMC Genomics, 2022 Background Repetitive sequences and mobile elements make up considerable fractions of individual genomes. While transposition events can be detrimental for organismal fitness, repetitive sequences form an enormous reservoir for molecular innovation.
Marina Athanasouli +1 more
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Normalization of genomic DNA using duplex-specific nuclease
BioTechniques, 2010 An application of duplex-specific nuclease (DSN) normalization technology to whole-genome shotgun sequencing of genomes with a large proportion of repetitive DNA is described.
Irina Shagina +5 more
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Chromosomal Differentiation of Deschampsia (Poaceae) Based on Four Satellite DNA Families
Frontiers in Genetics, 2021 Diverse families of satellite DNA (satDNA) were detected in heterochromatin regions of Deschampsia. This kind of repetitive DNA consists of tandem repeat sequences forming big arrays in genomes, and can contribute to lineages differentiation.
María Laura González +2 more
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Epigenetics and triplet repeat neurological diseases
Frontiers in Neurology, 2015 The term ‘junk DNA’ has been reconsidered following the delineation of the functional significance of repetitive DNA regions. Typically associated with centromeres and telomeres, DNA repeats are found in nearly all organisms throughout their genomes ...
Sathiji eNageshwaran +1 more
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