Results 71 to 80 of about 1,761,722 (244)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Stretching the Rules: Monocentric Chromosomes with Multiple Centromere Domains [PDF]

, 2012
The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3.
Elizabeth Schroeder-Reiter, Schroeder-Reiter, Elizabeth, Chocholova, Eva, Neumann Pavel, Novák Petr, Petr Novák (2448673), Navrátilová Alice, Wanner, Gerhard, Macas Jiří, Gerhard Wanner (40161), Petr Novák, Koblížková Andrea, Jiří Macas (84231), Pavel Neumann, Steinbauerova, Veronika, Navratilova, Alice, Elizabeth Schroeder-Reiter (156901), Andrea Koblížková, Eva Chocholová (156910), Veronika Steinbauerová, Alice Navrátilová (84233), Macas, Jiri, Pavel Neumann (84232), Andrea Koblížková (156904), Neumann, Pavel, Koblizkova, Andrea, Eva Chocholová, Schroeder-Reiter Elizabeth, Wanner Gerhard, Jiří Macas, Veronika Steinbauerová (156907), Novak, Petr, Alice Navrátilová, Gerhard Wanner, Steinbauerová Veronika, Chocholová Eva   +35 more
core   +2 more sources

Shedding light on DNA methylation and its clinical implications: the impact of long-read-based nanopore technology

Epigenetics & Chromatin
DNA methylation is an essential epigenetic mechanism for regulation of gene expression, through which many physiological (X-chromosome inactivation, genetic imprinting, chromatin structure and miRNA regulation, genome defense, silencing of transposable ...
Alexandra Chera, Mircea Stancu-Cretu, Nicolae Radu Zabet, Octavian Bucur   +3 more
doaj   +1 more source

Automated paleontology of repetitive DNA with REANNOTATE

BMC Genomics, 2008
Background Dispersed repeats are a major component of eukaryotic genomes and drivers of genome evolution. Annotation of DNA sequences homologous to known repetitive elements has been mainly performed with the program REPEATMASKER.
Pereira Vini
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Replicating repetitive DNA [PDF]

, 2016
The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating ...
Silvia Tognetti, Speck, C, Christian Speck, Tognetti, S   +3 more
core   +1 more source

Application of primed in situ DNA synthesis (PRINS) with telomere human commercial kit in molecular cytogenetics of Equus caballus and Sus scrofa scrofa.

Folia Histochemica et Cytobiologica, 2008
Recently, molecular techniques have become an indispensable tools for cytogenetic research. Especially, development of in situ techniques made possible detection at the chromosomal level, genes as well as repetitive sequences like telomeres or the DNA ...
Maciej Wnuk, Monika Bugno, Ewa Slota
doaj   +1 more source