Results 181 to 190 of about 28,497 (308)

The Effect of Dopaminergic Medication on Impulse Control and Compulsive Behaviour: A Translational Perspective

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Dopaminergic medication used in disorders like Parkinson's disease (PD) and restless legs syndrome can cause impulsive‐compulsive behaviour (ICB), often with strong negative effects on patients' quality of life. This narrative review presents translational evidence on iatrogenic ICB, taking findings from epidemiological, clinical, neuroimaging
Mirjam Wolfschlag   +7 more
wiley   +1 more source

Interhemispheric Metabolic Effects of Transcranial Infrared Laser Stimulation of the Prefrontal Cortex

open access: yesHuman Brain Mapping, Volume 47, Issue 9, June 15, 2026.
Unilateral prefrontal TILS reliably increases ipsilateral cytochrome‐c‐oxidase and oxygenated hemoglobin, demonstrating dose‐dependent metabolic efficacy without adverse effects. Contralateral responses are asymmetric: changes emerge later and differ by stimulation side, with stronger right‐hemisphere effects after left‐sided TILS, suggesting ...
Patrick O'Connor   +4 more
wiley   +1 more source

Emerging directions in tauopathy research

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Luc Buée   +41 more
wiley   +1 more source

Improving the clinical trial landscape for patients with atypical variants of Alzheimer's disease: a call to action

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non‐amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large‐scale clinical trials, which typically focus on late‐onset, sporadic amnestic ...
Nick Corriveau‐Lecavalier   +36 more
wiley   +1 more source

The include network: Advancing cross‐linguistic equity in brain health research

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Speech and language measures are increasingly recognized as sensitive, scalable, non‐invasive markers of diverse brain disorders. Yet, current research is overwhelmingly English‐centric, neglecting the world's vast linguistic diversity and undermining these markers’ global applicability.
Adolfo M. García   +13 more
wiley   +1 more source

Redirecting Alzheimer's disease therapeutics: Multitarget drugs and complementary non‐pharmacological strategies

open access: yesAlzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder driven by intersecting pathological processes. Persistent attrition in AD drug‐development pipelines highlights the limited clinical impact of single‐target therapies and has increased interest in multi‐target approaches acting on shared biological hubs.
Humberto Martínez‐Orozco   +4 more
wiley   +1 more source

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