Results 81 to 90 of about 3,207,924 (350)

Non-neoplastic indications and outcomes of the proximal and distal femur megaprosthesis: a critical review

open access: yesKnee Surgery & Related Research, 2020
Purpose Megaprosthesis or endoprosthetic replacement of the proximal and distal femur is a well-established modality for treatment of tumors. The indications for megaprosthesis have been expanded to the treatment of some non-neoplastic conditions of the ...
Raju Vaishya   +2 more
doaj   +1 more source

Impacts of Strike Replacement Bans in Canada [PDF]

open access: yes
In the labor relations area no issue generates as much controversy and division between labor and management as does the legislative ban on replacement workers.
Joseph Tracy   +2 more
core  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

The Use of Replacement Workers in Union Contract Negotiations: The U.S. Experience, 1980-1989 [PDF]

open access: yes
It is argued in many circles that a structural change occurred in U.S. collective bargaining in the 1980s. Strike incidence declined, dispute incidence increased, and the composition of disputes shifted away from strikes and toward holdouts.
Joseph S. Tracy, Peter Cramton
core  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

The Replace Operator [PDF]

open access: yesProceedings of the 33rd annual meeting on Association for Computational Linguistics -, 1995
This paper introduces to the calculus of regular expressions a replace operator and defines a set of replacement expressions that concisely encode alternate variations of the operation. Replace expressions denote regular relations, defined in terms of other regular expression operators. The basic case is unconditional obligatory replacement. We develop
openaire   +2 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Generic homonyms in the Colydiinae (Coleoptera: Zopheridae) [PDF]

open access: yes, 2001
New replacement names are proposed: Megapnosaurus Ivie, Slipinski and Wegrzynowicz NEW REPLACEMENT NAME for Syntarsus Raath 1969 (Ceratosauria: Coelophysidae), not Syntarsus Fairmaire 1869 (Coleoptera: Zopheridae: Colydiinae); and Stephaniolus Ivie ...
Ivie, Michael A.   +2 more
core   +1 more source

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