Results 111 to 120 of about 868,934 (253)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Number of deceased organ donors per year from 1991 to 2010 in Ontario.

, 2013
Expected (blue line) represents the number of deceased organ donors as reported by the Canadian Organ Replacement Registry. Identified (red line) represents the number of deceased organ donors as reported by our physician billing algorithm.
Greg Knoll (163065), Jagadish Rangrej (75172), Damon C. Scales (445773), Donald A. Redelmeier (237167), S. Joseph Kim (445772), Alvin Ho-ting Li (445771), Ann Young (445775), Salimah Shariff (445774), Amit X. Garg (445776)   +8 more
core   +1 more source

Initial trends of individual donation nucleic acid testing in voluntary & replacement donors from a tertiary care centre in north India. [PDF]

Indian J Med Res, 2019
Hans R, Marwaha N, Sharma S, Sachdev S, Sharma RR.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Split-liver transplantation with pediatric donors: a multicenter experience

, 2005
BACKGROUND: Outcomes of split-liver transplantation (SLT) with pediatric donors have never been specifically reported. METHODS: A prospective multicenter study on SLT using donors younger than 15 years was conducted. Thirty-nine split-liver procedures
Rogiers, X, Santamaria, ML, P. Reggiani, Giuseppe Tisone, Lopez Santamaria, Manuel, Tisone, Giuseppe, X. Rogiers, Rossi, Giorgio, Valente, U, Manuel Lopez Santamaria, Matteo Cescon, Santamaria, ML, Baccarani, U, Majno, P, Bruno Gridelli, Scalamogna, Mario, Xavier Rogiers, Reggiani, Paolo, Gridelli, B, Giorgio Rossi, Rogiers, XavierGE38000070620444802000113507F5AA269A-F0ED-11E1-A9DE-61C894A0A6B4, Cescon, Matteo, Majno, Pietro, G. Tisone, Pietro Majno, Grazi, Gian Luca, Santamaria, Manuel Lopez, B. Gridelli, Spada, Marco, Grazi, GL, U. Baccarani, Umberto Valente, Gridelli, Bruno, Colledan, M, Andorno, E, Valente, U, ROSSI, MASSIMO, Andorno, Enzo, Rogiers, Xavier, M. Rossi, Ettorre, Giuseppe Maria, Tisone, G, Colledan, Michele, G. M. Ettorre, U. valente, M. Scalamogna, E. Adorno, Cillo, U, Colledan, M, Spada, M, G. Rossi, Giuseppe Maria Ettorre, M. Spada, Reggiani, P, Mario Scalamogna, Gian Luca Grazi, M. Cescon, Michele Colledan, U. Cillo, Cescon, M, Valente, Umberto, Umberto Cillo, Marco Spada, Enzo Andorno, M. Colledan, Rossi, G, Umberto Baccarani, Rogiers, X, Scalamogna, M, Andorno, E, Ettorre, GM, Paolo Reggiani, P. Majno, Rossi, M, M. L. Santamaria, Gridelli, B., G. L. Grazi, COLLEDAN M, Ettorre G. M., CESCON M, Andorno E., ANDORNO E, Colledan M., CILLO, UMBERTO, Rossi M., SCALAMOGNA M, BACCARANI U, SPADA M, GRIDELLI B., Cescon M., Majno P., Scalamogna M., Baccarani U., Tisone G., VALENTE U, Rossi G., ETTORRE GM, Rogiers X., MAJNO P, TISONE G, Grazi G. L., Cillo U., SANTAMARIA ML, GRAZI GL, ROGIERS X, CILLO U, REGGIANI P, Valente U., Spada M., ROSSI G, Santamaria M. L., Reggiani P., BACCARANI, Umberto, ROSSI M   +110 more
core   +1 more source

Frekuensi HBsAg Positif pada Uji Saring Darah di Palang Merah Indonesia Cabang Padang Tahun 2012

Jurnal Kesehatan Andalas, 2015
Abstrak Infeksi virus hepatitis B dapat berkembang menjadi hepatitis kronis, sirosis hati, kanker hati dan bahkan kematian. Salah satu cara penularannya adalah melalui transfusi darah.
Nadia Ventiani, Susila Lastri, Dian Pratiwi   +2 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An investigation into blood donation intentions among non-donors

, 2008
In broad terms, the donation of blood along with organ and bone marrow donation is considered to be the ultimate act of humanity involving a voluntary and anonymous exchange between two people of a life saving commodity.
Angela Wood (90041), Michael Reid (18030910)   +1 more
core  

Self-reported high-risk behavior among first-time and repeat replacement blood donors; a four-year retrospective study of patterns.

PLoS ONE
BackgroundThere is no replacement for blood, and patients requiring transfusion depend on human donors, most of whom are family donors. Family donors may deny engagement in high-risk activities, which threaten the safety of donated blood.
Felix Osei-Boakye, Charles Nkansah, Samuel Kwasi Appiah, Gabriel Abbam, Gabriel Abbam, Charles Angnataa Derigubah, Boniface Nwofoke Ukwah, Victor Udoh Usanga, Emmanuel Ike Ugwuja, Ejike Felix Chukwurah   +9 more
doaj   +1 more source