Results 161 to 170 of about 30,232 (267)

Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study. [PDF]

Nat Commun
Goltermann J, Winter NR, Meinert S, Grotegerd D, Kraus A, Flinkenflügel K, Altegoer L, Krieger J, Leehr EJ, Böhnlein J, Bonnekoh LM, Richter M, Hahn T, Fisch L, Gruber M, Hermesdorf M, Berger K, Arolt V, Brosch K, Stein F, Thomas-Odenthal F, Usemann P, Teutenberg L, Hammes V, Jamalabadi H, Alexander N, Straube B, Jansen A, Nenadić I, Kircher T, Opel N, Dannlowski U.   +31 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Characterizing replicability in the clustering structure of brain morphology in autism, attention-deficit/hyperactivity disorder, and obsessive compulsive disorder. [PDF]

Transl Psychiatry
Sadat-Nejad Y, Vandewouw MM, Brian J, Crosbie J, Schachar RJ, Iaboni A, Kelley E, Jones J, Taylor MJ, Ayub M, Nicolson R, Syed B, Hammill C, Georgiades S, Arnold PD, Lerch JP, Anagnostou E, Kushki A.   +17 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Author Correction: On the replicability of diffusion weighted MRI-based brain-behavior models. [PDF]

Commun Biol
Kotikalapudi R, Kincses B, Gallitto G, Englert R, Hoffschlag K, Li J, Büchel C, Bingel U, Spisak T.   +8 more
europepmc   +1 more source

Replication Publication

PLoS Biology, 2005
Mark Patterson, Lon Cardon
openaire   +4 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Metascientific replication project with the advanced meta-experimental protocol of the transparent psi project procedures for testing the precognitive effect claimed by Bem. [PDF]

PLoS One
Walleczek J, von Stillfried N, Schmidt S, Wittmann M, Kirmse KA, Moll J, Kekecs Z.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A systematic review of methylome-wide associations with anxiety disorders. [PDF]

Transl Psychiatry
Ingram SJ, Zillich L, Schiele MA, Psychiatric Genomics Consortium Anxiety Epigenetics Workgroup, Domschke K, Hettema JM, Clark SL.   +6 more
europepmc   +1 more source