Results 141 to 150 of about 1,173,714 (339)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Reproducibility vs. Replicability: A Brief History of a Confused Terminology
Frontiers in Neuroinformatics, 2018 Hans E. Plesser, Hans E. Plesser
doaj +1 more source
HydrologyPerforming infiltration experiments on sieved and repacked soil columns seems a generally underrated topic from a methodological point of view. This study assessed how the descriptive parameters of the infiltration process were influenced by (i) the ...
Vincenzo Bagarello +5 more
doaj +1 more source
How open is open source: Software and beyond [PDF]
Traditionally the protection of intellectual property is regarded as a precondition for value capture. The rise of open source (OS) software and OS tangible products, so-called open design, has challenged this understanding. Openness is often regarded as
Balka, Kerstin +2 more
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Media and CommunicationIncreasing awareness of the “replication crisis” has prompted discussion about replicability and reproducibility in social and behavioral science research, including in communication. As with other fields, communication has seen discussion about concerns
James D. Ivory
doaj +1 more source
, 2016 To continue the chain of infection, a virus must undergo the process of replication to create new, infectious virions that are able to infect other cells of the body or subsequent hosts. After gaining entry into the body, a virus makes physical contact with and crosses the plasma membrane of a target cell.
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Implementing the Linear Adaptive False Discovery Rate Procedure for Spatiotemporal Trend Testing
MathematicsStatistical inference in spatiotemporal trend analysis often involves testing separate hypotheses for each pixel in datasets containing thousands of observations.
Oliver Gutiérrez-Hernández +1 more
doaj +1 more source