Results 121 to 130 of about 220,529 (335)
Replicability of Tightness–Looseness Scale in a Brazilian Sample: Validity and Challenges
Open PsychologyThe strength of social norms and their sanctions characterizes a culture. However, their measurement is challenging, and some forms of operationalization seem to have partial success, as in the case of the Tightness–Looseness (TL) Scale. This study aimed
Mazzoleni Martina +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
LinguisticsIn recent years, numerous fields of research have seen a push for increased reproducibility and transparency. As a result, specific transparency practices have emerged, such as open access publishing, preregistration, sharing data, analyses, and code ...
Casillas Joseph V. +15 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The Difference Between "Replicable" and "Not replicable" is not Itself Scientifically Replicable
Replication studies estimate the replicability rate of scientific results by aggregating binary verdicts of experiments. Exact replications are rarely attainable, so most replication sequences are non-exact. Experiments differ in ways that matter and do not share a single data-generating process.
Devezer, Berna, Buzbas, Erkan O.
openaire +2 more sources
On the Necessity of Validating Antibodies in the Immunohistochemistry Literature
Frontiers in Neuroanatomy, 2019 Laurent Gautron
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source