Results 101 to 110 of about 1,173,714 (339)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Optimistic replication [PDF]

open access: yesACM Computing Surveys, 2005
Data replication is a key technology in distributed systems that enables higher availability and performance. This article surveys optimistic replication algorithms. They allow replica contents to diverge in the short term to support concurrent work practices and tolerate failures in low-quality communication links. The importance of such techniques is
Saito, Yasushi, Shapiro, Marc
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

metajelo: A Metadata Package for Journals to Support External Linked Objects [PDF]

open access: yes, 2019
We propose a metadata package that is intended to provide academic journals with a lightweight means of registering, at the time of publication, the existence and disposition of supplementary materials.
Lagoze, Carl, Vilhuber, Lars
core   +1 more source

Methodological reporting behavior, sample sizes, and statistical power in studies of event-related potentials: Barriers to reproducibility and replicability.

open access: yesPsychophysiology, 2019
Methodological reporting guidelines for studies of ERPs were updated in Psychophysiology in 2014. These guidelines facilitate the communication of key methodological parameters (e.g., preprocessing steps).
P. Clayson   +3 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

A Systematic Review of Eye-Tracking Technology in Second Language Research

open access: yesLanguages
Eye-tracking has become increasingly popular in second language (L2) research. In this study, we systematically reviewed 111 eye-tracking studies published in 17 L2 journals to explore the application and replicability of eye-tracking technology in L2 ...
Xin Hu, Vahid Aryadoust
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A practical, step-by-step, guide to taxonomic comparisons using Procrustes geometric morphometrics and user-friendly software (part A): introduction and preliminary analyses

open access: yesEuropean Journal of Taxonomy
Taxonomy lays the foundations for the study of biodiversity and its conservation. Procrustean geometric morphometrics (GMM) is a most common technique for the taxonomic assessment of phenotypic population differences.
Andrea Cardini
doaj   +1 more source

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