Results 61 to 70 of about 56,188 (281)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Replica attack detection method for vehicular ad hoc networks with sequential trajectory segment

open access: yesInternational Journal of Distributed Sensor Networks, 2019
In vehicular ad hoc networks, attackers can disguise as replicas of legitimate vehicles by cracking or colluding and then use the identity replicas in a malicious way.
Yan Xin, Xia Feng
doaj   +1 more source

Advanced Perceptive Forwarding in Content-Centric Networks

open access: yesIEEE Access, 2017
As the promising communication architecture for future networks, the content-centric network (CCN) is still facing many challenges. In CCNs, it is difficult to discover temporary content replicas spreading in routers' caches based on the routing ...
Bing Li, Maode Ma, Xinbin Yang
doaj   +1 more source

High resolution replicas [PDF]

open access: yes, 1988
Disclosed are improved methods for preparing high resolution replicas for electron microscopic analysis. Replicas are prepared having a resolution capability less than ten angstroms, with structures of even less than five angstroms being readily ...
Mizuta, Shun, Brown, R. Malcolm, Jr.
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Ultrasonic wave propagation in stereo-lithographical bone replicas [PDF]

open access: yes, 2010
Predictions of a modified anisotropic Biot–Allard theory are compared with measurements of pulses centered on 100 kHz and 1 MHz transmitted through water-saturated stereo-lithographical bone replicas.
Lauriks, Walter   +9 more
core   +1 more source

Biomimetic replicas of plants surfaces

open access: yes, 2023
Images of epoxy replicas of plant surfaces obtained by a two-step moulding process. A first negative mould is obtained using a polyvinylsiloxane polymer and then the positive replica is obtained using an adequate epoxy resin.
Pedro Miguel Matos Pereira (639972)   +3 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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