Results 101 to 110 of about 1,395,428 (175)

Bats generate lower affinity but higher diversity antibody responses than those of mice, but pathogen-binding capacity increases if protein is restricted in their diet.

PLoS Biology
Bats are reservoirs of many zoonotic viruses that are fatal in humans but do not cause disease in bats. Moreover, bats generate low neutralizing antibody titers in response to experimental viral infection, although more robust antibody responses have ...
Daniel E Crowley, Caylee A Falvo, Evelyn Benson, Jodi Hedges, Mark Jutila, Shahrzad Ezzatpour, Hector C Aguilar, Manuel Ruiz-Aravena, Wenjun Ma, Tony Schountz, Agnieszka Rynda-Apple, Raina K Plowright   +11 more
doaj   +1 more source

Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep.

, 2013
Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to ...
Hoffmann, B., C.C.P. Celma, Wernike, Kerstin, Eschbaumer, M., Wernike, K., De Clercq, K., van Rijn, Piet A, Haegeman, Andy, Beer, M., B. Hoffmann, A. Haegeman, P.A. van Rijn, van Rijn, P.A., Clercq, K., De, Celma, C.C.P., Eschbaumer, Michael, P. Roy, Boyce, Mark, Roy, Polly, M. Boyce, Roy, P., Hoffmann, Bernd, De Clercq, Kris, Rijn, P.A., van, M. Beer, Boyce, M., M. Eschbaumer, Celma, Cristina CP, K. De Clercq, Beer, Martin, K. Wernike, Haegeman, A.   +31 more
core   +1 more source

Generation of High-Titer Defective HSV-1 Vectors Using an IE 2 Deletion Mutant and Quantitative Study of Expression in Cultured Cortical Cells

BioTechniques, 1996
Vectors based on herpes simplex virus type 1 (HSV-1) show promise for gene transfer into mammalian cells because of their wide host range, efficient infection and ability to deliver genes to nondividing cells.
F. Lim, D. Hartley, P. Starr, P. Lang, S. Song, L. Yu, Y. Wang, A.I. Geller   +7 more
doaj   +1 more source

The extreme C terminus of herpes simplex virus DNA polymerase is crucial for functional interaction with processivity factor UL42 and for viral replication [PDF]

, 1993
The herpes simplex virus DNA polymerase is composed of two subunits, a large catalytic subunit (Pol) and a smaller subunit (UL42) that increases the processivity of the holoenzyme.
Bebrin, William R, Paul Digard, M. Coen, Digard, Paul, Weisshart, Klaus, Klaus Weisshart, Coen, Donald M, William R. Bebrin, Donald   +8 more
core  

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein [PDF]

, 2016
Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) has recently caused several major outbreaks affecting millions of people. There are no licensed vaccines or antivirals, and the knowledge of the molecular biology of CHIKV, crucial for ...
Ahola, Tero, Utt, Age, Saul, Sirle, Merits, Andres, Age Utt, Quirin, Tania, Hellstrom, Kirsi, Tero Ahola, Andres Merits, Sirle Saul, Kirsi Hellström, Tania Quirin   +11 more
core   +2 more sources

Studies on influenza A virus PB1-F2 protein [PDF]

, 2011
The influenza A virus genome codes for up to 12 proteins. Segment 2 encodes three proteins, the polymerase subunit PB1, a small protein PB1-F2 and an N-terminally truncated version of PB1 called N40. Different functions have been reported for PB1-F2 such
Vater, Sandra
core   +2 more sources

Immunogenicity and Protective Efficacy of Replication-Incompetent Influenza Virus-Like Particles [PDF]

, 2002
Despite the success of influenza virus vaccines in reducing severe illness, their efficacy is suboptimal. We describe here the immunogenicity and protective capacity of replication-incompetent influenza virus-like particles (VLPs) which were generated ...
Kawaoka, Yoshihiro, Watanabe, Shinji, Neumann, Gabriele, Watanabe, Tokiko, Kida, Hiroshi   +4 more
core   +1 more source

Evidence for Powassan virus deletions and defective RNA in field-collected ticks

Journal of Virology
Powassan virus (POWV) is a tick-borne flavivirus endemic to the United States, Canada, and parts of Russia. POWV remains an under-studied pathogen, despite the potential for serious and life-threatening neurologic complications following infection. While
Samantha J. Courtney, Rose M. Langsjoen, Chasity E. Trammell, Rebecca M. Robich, Heidi K. Goethert, Rebekah J. McMinn, Sam R. Telford, Gregory D. Ebel, Anne Piantadosi   +8 more
doaj   +1 more source

Regulation of adenovirus replication by miR-199 confers a selective oncolytic activity in hepatocellular carcinoma [PDF]

, 2012
Oncolytic virotherapy represents a growing field of experimental cancer therapy. For safe and effective virotherapy, restricted tissue expression and replication of the virus is desirable.
Khalid Elamin Elhag, Baha Eldin
core  

A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice.

PLoS ONE
Herpes Simplex virus (HSV) is the cause of genital herpes and no prophylactic treatment is currently available. Replication-incompetent adenoviral vectors are potent inducers of humoral and cellular immune responses in humans.
Elisa Rossetti, Marija Vujadinovic, Ella van Huizen, Jeroen Tolboom, Hanneke Schuitemaker, Feng Yao, Roland Zahn, Eirikur Saeland   +7 more
doaj   +1 more source