Results 171 to 180 of about 1,185,258 (299)

Metabolic Hostile Takeover: How Influenza Virus Reprograms Cellular Metabolism for Replication. [PDF]

Viruses
Hui X, Tian X, Ding S, Gao G, Zhao X, Cui J, Hou Y, Zhao T, Wang H.   +8 more
europepmc   +1 more source

Replication of viral RNA, XVI. Enzymatic synthesis of infectious virual RNA with noninfectious Q-beta minus strands as template.

, 1968
G. Feix, R J Pollet, C. Weissmann
openalex   +1 more source

REPLICATION OF CHROMATIN IN MOUSE MAMMARY EPITHELIAL CELLS GROWN IN VITRO [PDF]

, 1965
Kathleen Church
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages. [PDF]

Nat Commun
Dramé M, Garcia-Rodriguez FJ, Ershov D, Martyn JE, Tinevez JY, Buchrieser C, Escoll P.   +6 more
europepmc   +1 more source

Self-replication [PDF]

Current Biology, 2003
Paul, Natasha, Joyce, Gerald F
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Alternative Lengthening of Telomeres: A Prognostic Paradox in Cancer. [PDF]

Cells
Sung JY.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Distinct roles of RECQL5 in RAD51-mediated fork reversal and transcription elongation. [PDF]

Nucleic Acids Res
Nagraj T, Sahoo S, Kadupatil S, Nagaraju G.   +3 more
europepmc   +1 more source