Results 181 to 190 of about 1,569,783 (304)

Molecular Mechanisms of Getah Virus Pathogenesis. [PDF]

Vet Sci
Sharif MU, Liu C, Qiu Y.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

The NS4B A119T mutation of dengue virus 2 confers adaptation to mammalian cells and increased pathogenicity in AG129 mice. [PDF]

J Gen Virol
Tabata K, Itakura Y, Uemura K, Mulavu M, Yamashita M, Matsushita T, Kusakabe S, Toba S, Sasaki M, Saito S, Gonzalez G, Hall WW, Sawa H, Sato A, Orba Y.   +14 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Evaluation of replication success: A statistical perspective and extended analysis of the SCORE data. [PDF]

PLoS One
van Aert RCM, van Assen MALM, López-Nicolás R.   +2 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Characterizing HIV expression of proviruses during ART in tissues and blood

Journal of Virus Eradication, 2017
W.R. McManus, M.J. Bale, A. Musick, J. Spindler, A. Wiegand, X. Wu, D. Wells, S.H. Hughes, B.F. Keele, R. Hoh, J. Milush, J.M. Coffin, J.W. Mellors, S.G. Deeks, M.F. Kearney   +14 more
doaj   +1 more source

Non-coding RNA-mediated tug-of-war between emerging viruses and host antiviral defense: lessons from animal viruses. [PDF]

Emerg Microbes Infect
Chen N, Zhang B, Yu Z, Tong G, Jin J, Jiang Q, Chen X.   +6 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Increased replication-associated single-stranded DNA promotes formaldehyde-induced mutagenesis in Saccharomyces cerevisiae. [PDF]

Genetics
Blouin T, McGuinness C, Marshall K, Bazzle C, Saini N.   +4 more
europepmc   +1 more source