Results 91 to 100 of about 76,259 (304)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

DNA2 drives processing and restart of reversed replication forks in human cells [PDF]

, 2015
Accurate processing of stalled or damaged DNA replication forks is paramount to genomic integrity and recent work points to replication fork reversal and restart as a central mechanism to ensuring high-fidelity DNA replication.
Alessandro Vindigni, Atkinson, Ayyagari, Bae, Berti, Budd, Budd, Budd, Bétous, Bétous, Carr, Cejka, Cejka, Cosimo Pinto, Cotta-Ramusino, Couch, Courcelle, Crabbe, Duxin, Eric A. Hendrickson, Eu Han Lee, Franchitto, Franken, Gari, Gravel, Hanada, Hashimoto, Hayley Moore, Henricksen, Hu, Kantake, Karanja, Karanja, Kumar, Kuo, Levikova, Liao, Machwe, Marko Vujanovic, Maryna Levikova, Massimo Lopes, Masuda-Sasa, Matteo Berti, Mendoza-Maldonado, Mimitou, Murfuni, Neelsen, Nicolette, Nimonkar, Niu, Peng, Petr Cejka, Pirzio, Ralph Zellweger, Ray Chaudhuri, Saravanabhavan Thangavel, Schlacher, Schlacher, Seigneur, Sheila Stewart, Shivasankari Gomathinayagam, Sidorova, Sidorova, Sturzenegger, Thangavel, Wawrousek, Wu, Yata, Yeo, Yin, Ying, Zellweger, Zeman, Zhu   +73 more
core   +3 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Efficient Arrangement of the Replication Fork Trap for In Vitro Propagation of Monomeric Circular DNA in the Chromosome-Replication Cycle Reaction

Life, 2018
Propagation of genetic information is a fundamental prerequisite for living cells. We recently developed the replication cycle reaction (RCR), an in vitro reaction for circular DNA propagation, by reconstitution of the replication cycle of the ...
Tomonori Hasebe, Kouhei Narita, Shiomi Hidaka, Masayuki Su’etsugu   +3 more
doaj   +1 more source

Coordinated protein and DNA remodeling by human HLTF and comparison of its activity with Bloom Syndrome helicase protein [PDF]

, 2011
Human HLTF (Helicase Like Transcription Factor) is a member of the Swi2/Snf2 family of ATP-driven molecular motor proteins. Like many members of Swi2/Snf2 family, HLTF does not exhibit a canonical DNA helicase activity but has an ATP hydrolysis-driven ...
Achar Yathish Jagadheesh
core  

Concerted activities of Mcm4, Sld3 and Dbf4 in control of origin activation and DNA replication fork progression [PDF]

, 2016
Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins in a temporally specific manner during S phase. The replicative helicase Mcm2-7 functions in both initiation and fork progression and thus is an important target of ...
Kinney, J. B., Sheu, Y. J., Stillman, B.   +2 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Roles of OB-Fold Proteins in Replication Stress

Frontiers in Cell and Developmental Biology, 2020
Accurate DNA replication is essential for maintaining genome stability. However, this stability becomes vulnerable when replication fork progression is stalled or slowed – a condition known as replication stress.
Dinh-Duc Nguyen, Eugene Y. Kim, Pau Biak Sang, Weihang Chai   +3 more
doaj   +1 more source

H2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly. [PDF]

PLoS Genetics, 2014
The influence of mono-ubiquitylation of histone H2B (H2Bub) on transcription via nucleosome reassembly has been widely documented. Recently, it has also been shown that H2Bub promotes recovery from replication stress; however, the underling molecular ...
Chia-Yeh Lin, Meng-Ying Wu, Sophie Gay, Lisette Marjavaara, Mong Sing Lai, Wei-Chun Hsiao, Shih-Hsun Hung, Hsin-Yi Tseng, Duncan Edward Wright, Chen-Yi Wang, Guoo-Shyng W Hsu, Didier Devys, Andrei Chabes, Cheng-Fu Kao   +13 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source