Results 51 to 60 of about 252,948 (297)
Pharmaceuticals, 2015 Seven novel N-arylsulfonyl-3-(2-yl-ethanone)-6-methylindole derivatives 4a–f and 6 were readily synthesized and have been identified as inhibitors of human immunodeficiency virus type-1 (HIV-1) replication. Initial biological studies indicated that among
Zhiping Che +5 more
doaj +1 more source
Tomographic reconstruction of weak, replicated index structures embedded in a volume
Optics Express, 2007 Measurements of weak, embedded index structures are important for material characterization of photopolymers, glass and other optical materials as well as for characterization of fabricated structures such as waveguides. We demonstrate an optical diffraction tomography system capable of measuring deeply-buried, weak, fabricated index structures written
Amy C, Sullivan, Robert R, McLeod
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
In Vitro Genotoxic Effects of Four Helichrysum Species in Human Lymphocytes Cultures
Biological Research, 2010 Helichrysum sanguineum, Helichrysum pamphylicum, Helichrysum orientale, Helichrysum noeanum (Asteraceae) are medicinal plants. For centuries, they have been used as tea in Turkey because of their medicinal properties.
Erhan H Erolu +4 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Community Resilience Index for Norway (Data and Replication Instructions)
, 2019 Data and replication instructions found here can be used to replicate the results presented in: Scherzer, Sabrina, Päivi Lujala and Jan Ketil Rød (2019).
Scherzer, S (via Mendeley Data)
core +1 more source
Using RDMA for Efficient Index Replication in LSM Key-Value Stores
CoRR, 2021 Log-Structured Merge tree (LSM tree) Key-Value (KV) stores have become a foundational layer in the storage stacks of datacenter and cloud services. Current approaches for achieving reliability and availability avoid replication at the KV store level and instead perform these operations at higher layers, e.g., the DB layer that runs on top of the KV ...
Michalis Vardoulakis +3 more
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Optimizing Costs to Collect Local Infauna through Grabs: Effect of Sampling Size and Replication
Diversity, 2020 Most ecological studies require a cost-effective collection of multi-species samples. A literature review unravelled that (1) large-sized grabs to collect infauna have been used at greater depths, despite no consistent relationship between grab size and ...
Lidia N. Álvarez +4 more
doaj +1 more source