Results 41 to 50 of about 260,016 (217)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Andrographia paniculata a Miracle Herbs for cancer treatment: In vivo and in vitro studies against Aflatoxin B1 Toxicity

open access: yesEgyptian Journal of Medical Human Genetics, 2014
Background: The history of natural products used in ancient times and in folk medicine these days, around the world, is the basis for the use of many therapeutic drugs in modern day medicine.
Md. Sultan Ahmad   +3 more
doaj   +1 more source

Optimizing Costs to Collect Local Infauna through Grabs: Effect of Sampling Size and Replication

open access: yesDiversity, 2020
Most ecological studies require a cost-effective collection of multi-species samples. A literature review unravelled that (1) large-sized grabs to collect infauna have been used at greater depths, despite no consistent relationship between grab size and ...
Lidia N. Álvarez   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Development and validation of a TOP2A based index clinical model for kidney renal clear cell carcinoma

open access: yesTranslational Oncology
Objective: TOP2A (Topoisomerase II alpha) is significantly overexpressed in kidney renal clear cell carcinoma (KIRC), and its expression level is significantly associated with accelerated tumor progression and poor prognosis in patients.
Xiaodong Shi   +10 more
doaj   +1 more source

Terminalia catappa, an anticlastogenic agent against MMS induced genotoxicity in the human lymphocyte culture and in bone marrow cells of Albino mice

open access: yesEgyptian Journal of Medical Human Genetics, 2014
Background: Terminalia catappa has been used as a folk medicine for treating dermatitis, hepatitis as well as other diseases in India. It possesses anticancer, antioxidant as well as anticlastogenic characteristics.
Mohammad Sultan Ahmad   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

In vitro anti-HSV-1 activity of a chemically sulfated galactomannan from Leucaena leucocephala seeds

open access: yesRevista de Ciências Farmacêuticas Básica e Aplicada, 2010
A galactomannan extracted from the seeds of Leucaena leucocephala was sulfated chemically, yielding a polymer (LLS-2) with 15.2% sulfate by weight (degree of sulfation 0.60), and its effect on the replication of Herpes simplex virus 1 (HSV-1) in Vero ...
E. Gemin   +5 more
doaj  

Cytogenetic studies of methotrexate drug on the peripheral blood samples from patients suffered of ulcerative colitis & ulcerative colitis developed to pseudopolyps &colon cancer

open access: yesمجلة مركز بحوث التقنيات الاحيائية, 2010
The investigation was done on 43 samples of peripheral blood which drawn from patients suffered of chronic ulcerative colitis, 20 samples from patients of colon cancer, 10 samples from ulcerative colitis developed to pseudopolyps & 20 samples of healthy
Zainab M. T. Jafer, Esmail K. Shubber
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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