Results 181 to 190 of about 695,037 (266)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

The regulatory roles of STAT3 protein in the pathogenesis of viral infections. [PDF]

Front Cell Infect Microbiol
Gu R, Zhang H, Xu E, Liu S.
europepmc   +1 more source

The Role of a C‐Terminal Seven‐Amino Acid Motif in TbCSV C3 Protein and Its Interaction With NbPOLA2 in Enhancing Viral Replication

Mingjun Li, Pengwei Huang, Zhou Jia, Xinyuan Lang, Lyuxin Wang, Zhen Gao, Hussein Ghanem, Gentu Wu, Ling Qing   +8 more
openalex   +1 more source

A Rab-GAP TBC Domain Protein Binds Hepatitis C Virus NS5A and Mediates Viral Replication

, 2007
Ella H. Sklan, Kirk A. Staschke, Tina M. Oakes, Menashe Elazar, Mark A. Winters, Benjamin Aroeti, Tsafi Danieli, Jeffrey S. Glenn   +7 more
openalex   +2 more sources

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

, 2020
Ying Wang, Sangwon Lee, Ya Ha, Wing Lam, Shaoru Chen, Ginger E. Dutschman, Elizabeth A. Gullen, Susan P. Grill, Yao Cheng, Alois Fürstner, Samson Francis, David C. Baker, Xiaoming Yang, Kuo‐Hsiung Lee, Yung‐Chi Cheng   +14 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A trans-activating transduction peptide fused nanobody targeting viral nonstructural protein NS4B inhibits bovine viral diarrhea virus replication. [PDF]

Front Immunol
Zhao B, Lv Z, Fan W, Zhang Y, Wei S, Fang J, Huang N, Chen X, Wang L, Qi X.   +9 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Quercetin Regulates Autophagy to Inhibit PRRSV Replication Through the PI3K/Akt/mTOR Signaling Pathway. [PDF]

Viruses
Yang Y, Li X, Shi H, Yu J, Gao C, Liu Y, Feng W, Peng L, Fu B, Yi P.   +9 more
europepmc   +1 more source