Results 1 to 10 of about 448,616 (266)
Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus. [PDF]
PLoS Biology, 2016 Positive-strand RNA viruses build extensive membranous replication compartments to support replication and protect the virus from antiviral responses by the host.
Kai Xu, Peter D Nagy
doaj +3 more sources
UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication.
PLoS Pathogens, 2017 Positive-strand RNA virus infections can induce the stress-related unfolded protein response (UPR) in host cells. This study found that enterovirus A71 (EVA71) utilizes host UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1), a key endoplasmic ...
Peng-Nien Huang +5 more
doaj +2 more sources
Viruses, 2021 The 3C-like protease (3CLpro) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases.
Jonathan M. O. Rawson +4 more
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mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon +9 more
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Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication
mBio, 2022 Frequent recombination is a hallmark of retrovirus replication. In rare cases, recombination occurs between distantly related retroviruses, generating novel viruses that may significantly impact viral evolution and public health.
Jonathan M. O. Rawson +10 more
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Microbiology Spectrum, 2022 HIV-1 must package its RNA genome to generate infectious viruses. Recent studies have revealed that during genome packaging, HIV-1 not only excludes cellular mRNAs, but also distinguishes among full-length viral RNAs. Using NL4-3 and MAL molecular clones,
Jonathan M. O. Rawson +5 more
doaj +1 more source
Endocytosis in Viral Replication [PDF]
Traffic, 2000 Although initially recognised as essential for the entry of certain viruses, endocytosis is now known to also play important roles in the replication of, and adaptation to, the host cell of a number of viruses. Here we consider several aspects of this association and recent results that have emerged to support this view.
M, Marsh, A, Pelchen-Matthews
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Cooperative nature of viral replication [PDF]
Science Advances, 2020 Group transmission of viruses accelerates early replication and increases short-term viral fitness.
Iván Andreu-Moreno +2 more
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Exploiting Connections for Viral Replication [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent on host cell metabolic machinery to survive and replicate, remodeling cellular membranes to generate sites of viral replication.
Wong, LH +4 more
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Molecular Therapy: Nucleic Acids, 2023 Gene therapy strategies that effectively inhibit HIV-1 replication are needed to reduce the requirement for lifelong antiviral therapy and potentially achieve a functional cure.
Krista A. Delviks-Frankenberry +5 more
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