Results 21 to 30 of about 507,151 (319)

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]

, 2002
Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Ruiz, L, Javier Martinez-Picado, Clotet, B, Frost, SDW, Martinez-Picado, J, Lidia Ruiz, Leigh Brown, AJ, Simon D. W. Frost, Bonaventura Clotet, Andrew J. Leigh Brown   +9 more
core   +1 more source

Analysis of the Replication Mechanisms of the Human Papillomavirus Genomes

Frontiers in Microbiology, 2021
The life-cycle of human papillomaviruses (HPVs) includes three distinct phases of the viral genome replication. First, the viral genome is amplified in the infected cells, and this amplification is often accompanied by the oligomerization of the viral ...
Lisett Liblekas, Alla Piirsoo, Annika Laanemets, Eva-Maria Tombak, Airiin Laaneväli, Ene Ustav, Mart Ustav, Marko Piirsoo   +7 more
doaj   +1 more source

Microtubules in viral replication and transport [PDF]

The Plant Journal, 2013
SummaryViruses use and subvert host cell mechanisms to support their replication and spread between cells, tissues and organisms. Microtubules and associated motor proteins play important roles in these processes in animal systems, and may also play a role in plants.
Niehl, Annette, Peña, Eduardo J., Amari, Khalid, Heinlein, Manfred   +3 more
openaire   +4 more sources

Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2 [PDF]

, 2005
In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 ...
Morgan, I.M., Cordano, P., Taylor, E.R., Everett, R., R. Everett, A. Okoye, M.S. Campo, P. Cordano, E.R. Taylor, Campo, M.S., I.M. Morgan, Okoye, A.   +11 more
core   +1 more source

Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G

Molecular Therapy: Nucleic Acids, 2019
Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure. To exploit the innate antiviral function of restriction factor cytidine deaminase APOBEC3G (A3G), we developed self-activating lentiviral vectors ...
Krista A. Delviks-Frankenberry, Daniel Ackerman, Nina D. Timberlake, Maria Hamscher, Olga A. Nikolaitchik, Wei-Shau Hu, Bruce E. Torbett, Vinay K. Pathak   +7 more
doaj   +1 more source

The KSHV ORF20 Protein Interacts with the Viral Processivity Factor ORF59 and Promotes Viral Reactivation

Microbiology Spectrum, 2021
Upon Kaposi’s Sarcoma-associated herpesvirus (KSHV) lytic reactivation, rapid and widespread amplification of viral DNA (vDNA) triggers significant nuclear reorganization.
D. Hoffman, W. Rodriguez, D. Macveigh-Fierro, J. Miles, M. Muller   +4 more
doaj   +1 more source

Viperin Poisons Viral Replication [PDF]

Cell Host & Microbe, 2018
Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.
Lisa F P, Ng, Julian A, Hiscox
openaire   +2 more sources

Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity

mBio, 2022
The relationship between spatiotemporal distribution of HIV-1 proviruses and their transcriptional activity is not well understood. To elucidate the intranuclear positions of transcriptionally active HIV-1 proviruses, we utilized an RNA fluorescence in ...
Ryan C. Burdick, Claire Deleage, Alice Duchon, Jacob D. Estes, Wei-Shau Hu, Vinay K. Pathak   +5 more
doaj   +1 more source

Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus. [PDF]

PLoS Biology, 2016
Positive-strand RNA viruses build extensive membranous replication compartments to support replication and protect the virus from antiviral responses by the host.
Kai Xu, Peter D Nagy
doaj   +1 more source

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo [PDF]

, 2011
There is increasing evidence for a connection between DNA replication and the expression of adjacent genes. Therefore, this study addressed the question of whether a herpesvirus origin of replication can be used to activate or increase the expression of ...
Mohr, Hermine, Eckhard Wolf, Marlon R. Schneider (160130), Ulrich H Koszinowski, Laura Scrivano (160134), Eckhard Wolf (39870), Koszinowski Ulrich H., Ruzsics, Zsolt, Schnieke Angelika, Christian A. Mohr (160123), Ulrich H. Koszinowski (152143), Marlon R. Schneider, Mohr Hermine, Schneider Marlon R., Dahlhoff, Maik, Hermine Mohr (160119), Zsolt Ruzsics (75383), Simone Kraner-Schreiber, Schneider, Marlon R., Christian A Mohr, Laura Scrivano, Kraner-Schreiber, Simone, Maik Dahlhoff, Simone Kraner-Schreiber (160141), Ruzsics Zsolt, Maik Dahlhoff (160144), Adler Barbara, Koszinowski, Ulrich H., Kraner-Scheiber, Simone, Zsolt Ruzsics, Mohr, Christian A., Kraner-Schreiber Simone, Schnieke, Angelika, Adler, Barbara, Wolf Eckhard, Dahlhoff Maik, Barbara Adler, Ulrich H. Koszinowski, Christian A. Mohr, Mohr Christian A., Scrivano Laura, Wolf, Eckhard, Hermine Mohr, Marlon R Schneider, Scrivano, Laura, Angelika Schnieke (133290), Barbara Adler (160138), Angelika Schnieke   +47 more
core   +1 more source