Results 41 to 50 of about 507,151 (319)

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P   +22 more
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Viral Replication

, 1987
Viral replication is the central focus of much experimental virology and is a significant part of molecular biology. Studies with bacteriophages in their prokaryotic host cells in the 1940s and 1950s provided the first insights into the complexities of viral replication. With the development of mammalian cell culture procedures, the techniques used for
FENNER, FRANK, BACHMANN, PETER A., GIBBS, E. PAUL J., MURPHY, FREDERICK A., STUDDERT, MICHAEL J., WHITE, DAVID O.   +5 more
openaire   +1 more source

Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. [PDF]

, 2012
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real ...
Lisa Marcinowski, Martina Rieder, Caroline C. Friedel (7812728), Marcinowski, Lisa, Lars Dölken, de Graaf, Miranda, Thomas Bonfert, Caroline C. Friedel (29226), Lars Dölken (138985), Györy, Ildiko, Caroline C Friedel, Philip Rosenstiel (68103), Jens B Bosse, Ruzsics, Zsolt, Ralf Zimmer, Bosse, Jens B., Lukas Windhager, Rosenstiel, Philip, Zsolt Ruzsics (75383), Jens B. Bosse (7812725), Zimmer, Ralf, Thomas Bonfert (138970), Rieder, Martina, Lisa Marcinowski (138962), Jens B. Bosse (138966), Friedel, Caroline C., Ildiko Györy (138972), Michael Lidschreiber, Ildiko Györy, Bernd Rädle (138968), Zsolt Ruzsics, Ralf Zimmer (21157), Windhager, Lukas, Miranda de Graaf, Philip Rosenstiel, Michael Lidschreiber (138963), Dölken, Lars, Olivia Prazeres da Costa, Prazeres da Costa, Olivia, Olivia Prazeres da Costa (138979), Bernd Rädle, Lukas Windhager (138964), Lidschreiber, Michael, Miranda de Graaf (138976), Bonfert, Thomas, Rädle, Bernd, Martina Rieder (138965)   +46 more
core   +1 more source

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
core   +1 more source

Identification and Molecular Characterization of the Chloroplast Targeting Domain of Turnip yellow mosaic virus Replication Proteins

Frontiers in Plant Science, 2017
Turnip yellow mosaic virus (TYMV) is a positive-strand RNA virus infecting plants. The TYMV 140K replication protein is a key organizer of viral replication complex (VRC) assembly, being responsible for recruitment of the viral polymerase and for ...
Lucille Moriceau, Lucille Moriceau, Lucile Jomat, Stéphane Bressanelli, Catherine Alcaide-Loridan, Isabelle Jupin   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The potato mop-top virus TGB2 protein and viral RNA associate with chloroplasts and viral infection induces inclusions in the plastids [PDF]

, 2012
The potato mop-top virus (PMTV) triple gene block 2 (TGB2) movement proteins fused to monomeric red fluorescent protein (mRFP-TGB2) was expressed under the control of the PMTV subgenomic promoter from a PMTV vector.
Roberts, Alison G., Cowan, Graham H., Angelika eZiegler, Ziegler, Angelika, Eugene I Savenkov, Lesley eTorrance, Angelika Ziegler, Lesley Torrance, Alison G Roberts, Torrance, Lesley, Sean N. Chapman, Graham H Cowan, Chapman, Sean N., Savenkov, Eugene I., Sean N Chapman, Alison G. Roberts, Chapman, Sean, Graham H. Cowan, Eugene I. Savenkov, Savenkov, Eugene   +19 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

Nature Communications, 2018
APOBEC3G (A3G) is a single-stranded DNA (ssDNA) cytidine deaminase that restricts HIV-1. Here the authors provide molecular insights into A3G substrate recognition by determining the 1.86 Å resolution crystal structure of its catalytic domain bound to ...
Atanu Maiti, Wazo Myint, Tapan Kanai, Krista Delviks-Frankenberry, Christina Sierra Rodriguez, Vinay K. Pathak, Celia A. Schiffer, Hiroshi Matsuo   +7 more
doaj   +1 more source

Kissing interaction between 3' noncoding and coding sequences is essential for porcine arterivirus RNA replication

, 2002
We used an infectious cDNA clone of Porcine reproductive and respiratory syndrome virus (PRRSV) to investigate the presence of essential replication elements in the region of the genome encoding the structural proteins.
R. C. L. Olsthoorn, Rottier, P.J.M., J. J. M. Meulenberg, Olsthoorn, R.R.C.L., M. H. Verheije, P. J. M. Rottier, M. V. Kroese, Meulenberg, J.J.M., Verheije, M.H., Olsthoorn, R.C.L., Kroese, M.V.   +10 more
core   +1 more source