Results 231 to 240 of about 695,037 (266)

Does Coxsackievirus B3 Require Autophagosome Formation for Replication? Evidence for an Autophagosome-Independent Mechanism: Insights into Its Limited Potential as a Therapeutic Target. [PDF]

Pharmaceuticals (Basel)
Ga YJ, Yeh JY.
europepmc   +1 more source

The temporal trends and short‐ and long‐term mortality of people with acute myocardial infarction and rheumatoid arthritis: a nationwide cohort study

Arthritis Care &Research, Accepted Article.
Aims We investigated whether a diagnosis of rheumatoid arthritis (RA) affects the quality of inpatient acute myocardial infarction (AMI) care and long‐term mortality post‐AMI. Methods We analysed data from 784,091 adults, 6,047 with a diagnosis of RA, from England and Wales hospitalised with AMI between 2005 and 2019 from the MINAP registry, linked ...
Megan Butler, Nicholas Weight, Muhammad Rashid, Rodrigo Bagur, Purvi Parwani, Samantha Hider, Edward Roddy, Robert Butler, Mamas A Mamas   +8 more
wiley   +1 more source

Regulatory hotspot on the influenza A virus polymerase revealed through the structure of the NEP-polymerase complex. [PDF]

Sci Adv
Rep A, Wang F, Chen KY, Carrique L, Sharps J, Grimes JM, Fodor E.   +6 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection. [PDF]

Nat Commun
Barreto-Galvez A, Niljikar M, Gagliardi JE, Guzman CP, Zhang R, Kumar V, Juwarwala A, Pradeep A, Saxena A, Montagna C, Mittal P, Gerhardt J, Xia B, Cao J, Kataoka K, Durbin AD, Qi J, Ye BH, Madireddy A.   +18 more
europepmc   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

Panduratin A from Boesenbergia rotunda suppresses hepatitis B virus by targeting HNF1α and synergizing with antiviral agents. [PDF]

Chin Med
Thongsri P, Pewkliang Y, Borwornpinyo S, Wongkajornsilp A, Ruenraroengsak P, Anurathapan U, Sobhonslidsuk A, Hongeng S, Sa-Ngiamsuntorn K.   +8 more
europepmc   +1 more source

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source

Bovine viral diarrhea virus suppresses type I IFN production by inducing MAVS degradation via autophagy mediated by the ROS-endoplasmic reticulum stress axis. [PDF]

J Virol
Wang J, Zhou J, Wang Y, Fan W, Xia X, Chen J, Zhu H, Wang Q, Li X, Liu Y, Xiang J, Yu H, Mao M, Xu R, Liu J, Jia S, Li Y, Xu Y.   +17 more
europepmc   +1 more source

Phosphatase PP2A promotes RTA dephosphorylation to impair KSHV lytic replication. [PDF]

PLoS Pathog
Bai L, Dong L, Dong J, Liang X, Peng J, Chen Y, Sun X, Chen Y, Li X, Cai H, Huang J, Cao Z, Lan K.   +12 more
europepmc   +1 more source