Results 91 to 100 of about 607,887 (313)

Statistics Reform: Practitioner’s Perspective

AppliedMath
It is widely believed that one of the main causes of the replication crisis in scientific research is some of the most commonly used statistical methods, such as null hypothesis significance testing (NHST).
Hening Huang
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation.

PLoS ONE, 2016
The aims of this systematic review were to determine which blood-based molecules have been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease (COPD) exacerbations (AECOPD) and to ascertain the quality of these biomarker ...
Yu-Wei Roy Chen, Janice M Leung, Don D Sin   +2 more
doaj   +1 more source

External Replication of Urinary Bladder Cancer Prognostic Polymorphisms in the UK Biobank

Frontiers in Oncology, 2019
Introduction: Multiple studies have reported genetic associations with prognostic outcomes of urinary bladder cancer. However, the lack of replication of these associations prohibits establishing further evidence-based research directions.
Nadezda Lipunova, Nadezda Lipunova, Nadezda Lipunova, Anke Wesselius, Kar K. Cheng, Frederik J. van Schooten, Jean-Baptiste Cazier, Jean-Baptiste Cazier, Richard T. Bryan, Maurice P. Zeegers, Maurice P. Zeegers   +10 more
doaj   +1 more source

Kinetic model of DNA replication in eukaryotic organisms

, 2003
We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition.
Avrami, Avrami, Avrami, Ben-Naim, Bensimon, Berezney, Blow, Blow, Blow, Blow, Blumenthal, Brewer, Buongiorno-Nardelli, Cahn, Cairns, Christian, Coverley, Friedman, Gilbert, Gomez, Hand, Herrick, Herrick, Huberman, Hyrien, Jackson, Jasny, Johnson, Kolmogorov, Laskey, Lu, Lucas, Mahbubani, Marheineke, Michalet, Mills, Pasero, Pierron, Plischke, Press, Raghuraman, Rowles, Sekimoto, Shinomiya, Shivashankar, Simon, Walter, Wu   +47 more
core   +1 more source

A statistical definition for reproducibility and replicability [PDF]

, 2016
AbstractEveryone agrees that reproducibility and replicability are fundamental characteristics of scientific studies. These topics are attracting increasing attention, scrutiny, and debate both in the popular press and the scientific literature. But there are no formal statistical definitions for these concepts, which leads to confusion since the same ...
Patil, Prasad, Peng, Roger D., Leek, Jeffrey T.   +2 more
openaire   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Statistical reform and the replication crisis

, 2018
The replication crisis has prompted many to call for statistical reform within the psychological sciences. Here we examine issues within Frequentist statistics that may have led to the replication crisis, and we examine the alternative---Bayesian statistics---that many have suggested as a replacement.
Colling, Lincoln J, Szucs, Denes
openaire   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Error-related negativity and the misattribution of state-anxiety following errors: On the reproducibility of Inzlicht and Al-Khindi (2012)

Frontiers in Human Neuroscience, 2016
In their innovative study, Inzlicht and Al-Khindi (2012) demonstrated that participants who were allowed to misattribute their arousal and negative affect induced by errors to a placebo beverage had a reduced error-related negativity (ERN/Ne) compared to
Carmen Cano Rodilla, André Beauducel, Anja Leue   +2 more
doaj   +1 more source