Results 91 to 100 of about 2,724,889 (347)
Statistics Reform: Practitioner’s Perspective
AppliedMathIt is widely believed that one of the main causes of the replication crisis in scientific research is some of the most commonly used statistical methods, such as null hypothesis significance testing (NHST).
Hening Huang
doaj +1 more source
A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation.
PLoS ONE, 2016 The aims of this systematic review were to determine which blood-based molecules have been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease (COPD) exacerbations (AECOPD) and to ascertain the quality of these biomarker ...
Yu-Wei Roy Chen +2 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
External Replication of Urinary Bladder Cancer Prognostic Polymorphisms in the UK Biobank
Frontiers in Oncology, 2019 Introduction: Multiple studies have reported genetic associations with prognostic outcomes of urinary bladder cancer. However, the lack of replication of these associations prohibits establishing further evidence-based research directions.
Nadezda Lipunova +10 more
doaj +1 more source
Kinetic model of DNA replication in eukaryotic organisms
, 2003 We formulate a kinetic model of DNA replication that quantitatively describes recent results on DNA replication in the in vitro system of Xenopus laevis prior to the mid-blastula transition.
Avrami +47 more
core +1 more source
Replicability in High Dimensional Statistics
2024 IEEE 65th Annual Symposium on Foundations of Computer Science (FOCS)119 ...
Hopkins, Max +4 more
openaire +3 more sources
Contingency and Statistical Laws in Replicate Microbial Closed Ecosystems [PDF]
Cell, 2012 Contingency, the persistent influence of past random events, pervades biology. To what extent, then, is each course of ecological or evolutionary dynamics unique, and to what extent are these dynamics subject to a common statistical structure? Addressing this question requires replicate measurements to search for emergent statistical laws. We establish
Hekstra, Doeke R., Leibler, Stanislas
openaire +2 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
An external exposome-wide association study of hypertensive disorders of pregnancy
Environment International, 2020 It is widely recognized that exogenous factors play an important role in the development of hypertensive disorders of pregnancy (HDP). However, only a few external environmental factors have been studied, often separately, with no attempt to examine the ...
Hui Hu +5 more
doaj +1 more source
Empirical validation of an agent-based model of wood markets in Switzerland. [PDF]
PLoS ONE, 2018 We present an agent-based model of wood markets and show our efforts to validate this model using empirical data from different sources, including interviews, workshops, experiments, and official statistics.
Stefan Holm +3 more
doaj +1 more source