Results 91 to 100 of about 2,474,205 (363)

External Replication of Urinary Bladder Cancer Prognostic Polymorphisms in the UK Biobank

Frontiers in Oncology, 2019
Introduction: Multiple studies have reported genetic associations with prognostic outcomes of urinary bladder cancer. However, the lack of replication of these associations prohibits establishing further evidence-based research directions.
Nadezda Lipunova, Nadezda Lipunova, Nadezda Lipunova, Anke Wesselius, Kar K. Cheng, Frederik J. van Schooten, Jean-Baptiste Cazier, Jean-Baptiste Cazier, Richard T. Bryan, Maurice P. Zeegers, Maurice P. Zeegers   +10 more
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Switching to Electronic Health Record Systems: A Replication of the User Resistance Model

AIS Trans. Replication Res., 2019
The purpose of this conceptual replication study is to understand the resistance construct of the User Resistance Model (URM) in the context of Health Information Technology (HIT) at an international healthcare organization.
Bahae Samhan, K. D. Joshi
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Error-related negativity and the misattribution of state-anxiety following errors: On the reproducibility of Inzlicht and Al-Khindi (2012)

Frontiers in Human Neuroscience, 2016
In their innovative study, Inzlicht and Al-Khindi (2012) demonstrated that participants who were allowed to misattribute their arousal and negative affect induced by errors to a placebo beverage had a reduced error-related negativity (ERN/Ne) compared to
Carmen Cano Rodilla, André Beauducel, Anja Leue   +2 more
doaj   +1 more source

Inferential statistics are descriptive statistics

, 2018
There has been much discussion of a "replication crisis" related to statistical inference, which has largely been attributed to overemphasis on and abuse of hypothesis testing.
Valentin Amrhein, D. Trafimow, S. Greenland   +2 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The Power of Replicated Measures to Increase Statistical Power

Advances in Methods and Practices in Psychological Science, 2019
When running statistical tests, researchers can commit a Type II error, that is, fail to reject the null hypothesis when it is false. To diminish the probability of committing a Type II error (β), statistical power must be augmented. Typically, this is done by increasing sample size, as more participants provide more power.
Marc-André Goulet, Denis Cousineau
openaire   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Replicability and impact of statistics in the detection of neural responses of consciousness.

Brain : a journal of neurology, 2016
Sir, We read with great interest the correspondence between Tzovara and colleagues and Naccache et al. regarding the neural detection of sound sequences in the absence of consciousness (Naccache et al. , 2015; Tzovara et al. , 2015 a , b ).
D. Gabriel, Emelyne Muzard, J. Henriques, C. Mignot, L. Pazart, N. André-Obadia, Juan-Pablo Ortega, T. Moulin   +7 more
semanticscholar   +1 more source