Results 121 to 130 of about 430,384 (331)
Do we focus on process over outcome? Review of published studies in two prominent saudi journals
Cogent EducationIt is well-known that published science is judged by the judicious and careful use of methods employed when acquiring knowledge and understanding. However, since the beginning of the millennia, concerns over the validity and reliability of scientific ...
Ruwayshid Alruwaili
doaj +1 more source
Statistical witchhunts: Science, justice & the p-value crisis [PDF]
arXiv, 2019 We provide accessible insight into the current 'replication crisis' in 'statistical science', by revisiting the old metaphor of 'court trial as hypothesis test'. Inter alia, we define and diagnose harmful statistical witch-hunting both in justice and science, which extends to the replication crisis itself, where a hunt on p-values is currently underway.
arxiv
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Do group ensemble statistics bias visual working memory for individual items? A registered replication of Brady and Alvarez (2011) [PDF]
, 2020 Frank Papenmeier, J. David Timm
openalex +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
BMJ OpenIntroduction Professional caregivers’ perspectives on dementia and on people living with dementia (PlwD) can influence their feelings, judgements and behaviours in work situations, for example, how they think about symptoms, disease progression and the ...
Johannes Michael Bergmann +8 more
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The assessment of replicability using the sum of p-values [PDF]
arXivStatistical significance of both the original and the replication study is a commonly used criterion to assess replication attempts, also known as the two-trials rule in drug development. However, replication studies are sometimes conducted although the original study is non-significant, in which case Type-I error rate control across both studies is no
arxiv
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee +5 more
wiley +1 more source
An external exposome-wide association study of hypertensive disorders of pregnancy
Environment International, 2020 It is widely recognized that exogenous factors play an important role in the development of hypertensive disorders of pregnancy (HDP). However, only a few external environmental factors have been studied, often separately, with no attempt to examine the ...
Hui Hu +5 more
doaj