Results 171 to 180 of about 2,308,235 (326)

Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health. [PDF]

Nat Aging
Jawinski P, Forstbach H, Kirsten H, Beyer F, Villringer A, Witte AV, Scholz M, Ripke S, Markett S.   +8 more
europepmc   +1 more source

EDITORIAL: Statistical significance, P-values, and replicability [PDF]

The Annals of Applied Statistics, 2021
openaire   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Serum microRNA expression quantitative trait loci in children with asthma colocalize with asthma-related GWAS results. [PDF]

NPJ Genom Med
Hecker J, Tiwari A, Sharma R, Mendez K, Li J, Begum S, Chen Q, Smith A, Celedón JC, Weiss ST, Kelly RS, Lasky-Su JA, Tantisira KG, McGeachie M.   +13 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases. [PDF]

Cell Death Dis
Okraine YV, de la Vega MB, Venerus Arbilla S, Moyano G, Bertolin AP, Pallarés HM, Wiesmüller L, Mansilla SF, Gottifredi V.   +8 more
europepmc   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling. [PDF]

Nat Commun
Chiou LF, Droby GN, Jayaprakash D, Anand JR, Zhang X, Yang Y, Mills CA, Webb TS, Barker NK, Xie J, Wu D, Herring LE, Tomida J, Bowser JL, Vaziri C.   +14 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Plasma Proteomic Profile of Dietary Potassium and Incident CKD. [PDF]

Clin J Am Soc Nephrol
Yang J, Bernard L, Chen J, Sullivan VK, Yu B, Rhee EP, Welling PA, Rebholz CM.   +7 more
europepmc   +1 more source