Results 51 to 60 of about 2,308,235 (326)

Statistics as a Social Activity: Attitudes toward Amalgamating Evidence

Entropy
Amalgamation of evidence in statistics is conducted in several ways. Within a study, multiple observations are combined by averaging, or as factors in a likelihood or prediction algorithm.
Andrew Gelman, Keith O’Rourke
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Data on microbial and physicochemical assessment of mixed fruit wine produced from physically damaged fruits

Data in Brief, 2018
The data described in this article was obtained in an experiment designed for the production of mixed fruit wine using physically damaged fruits in the process of fermentation.
Deborah O. Oba, Oluwaseun J. Okunola, Solomon U. Oranusi, Hilary I. Okagbue   +3 more
doaj   +1 more source

We need more replication research – A case for test-retest reliability

Perspectives on Medical Education, 2017
Following debates in psychology on the importance of replication research, we have also started to see pleas for a more prominent role for replication research in medical education.
J. Leppink, Patricia Pérez-Fuster
semanticscholar   +1 more source

Replicability in High Dimensional Statistics

2024 IEEE 65th Annual Symposium on Foundations of Computer Science (FOCS)
119 ...
Hopkins, Max, Impagliazzo, Russell, Kane, Daniel, Liu, Sihan, Ye, Christopher   +4 more
openaire   +3 more sources

Identifying Statistical Bias in Dataset Replication

, 2020
Dataset replication is a useful tool for assessing whether improvements in test accuracy on a specific benchmark correspond to improvements in models' ability to generalize reliably. In this work, we present unintuitive yet significant ways in which standard approaches to dataset replication introduce statistical bias, skewing the resulting ...
Engstrom, Logan, Ilyas, Andrew, Santurkar, Shibani, Tsipras, Dimitris, Steinhardt, Jacob, Madry, Aleksander   +5 more
openaire   +2 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source