Results 71 to 80 of about 779,107 (361)

Abandon Statistical Significance [PDF]

, 2018
We discuss problems the null hypothesis significance testing (NHST) paradigm poses for replication and more broadly in the biomedical and social sciences as well as how these problems remain unresolved by proposals involving modified p-value thresholds ...
Gal, David, Gelman, Andrew, McShane, Blakeley B., Robert, Christian, Tackett, Jennifer L.   +4 more
core   +2 more sources

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source

The Influence of PBL Model on Student Learning Outcomes in the Form Changes Concept of Substances

Jurnal Pijar MIPA (Pengkajian Ilmu dan Pengajaran Matematika dan Ilmu Pengetahuan Alam)
The problem-based learning (PBL) model is the learning model that prepares students to think critically and analytically. This study investigates the effect of the PBL model on students' academic performance related to the form changes concept of ...
Ismail Pakaya, Tirtawaty Abdjul, Citron S. Payu, Muhammad Yunus   +3 more
doaj   +1 more source

RHPMAN: Replication in Highly Partitioned Mobile Ad Hoc Networks

International Journal of Distributed Sensor Networks, 2014
Accessing data in mobile ad hoc networks is a challenging problem, which is caused by frequent network partitions due to node mobility and due to the impairments of wireless communications.
Ke Shi, Hongsheng Chen
doaj   +1 more source

Bayesian sample size determination for multi-site replication studies [PDF]

arXiv, 2023
An ongoing "reproducibility crisis" calls into question scientific discoveries across a variety of disciplines ranging from life to social sciences. Replication studies aim to investigate the validity of findings in published research, and try to assess whether the latter are statistically consistent with those in the replications.
arxiv  

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Mendelian randomization study shows a causal effect of asthma on epilepsy risk

Frontiers in Immunology, 2023
ObjectiveThe relationship between asthma and epilepsy in observational studies is controversial. The purpose of this Mendelian randomization (MR) study is to investigate whether asthma causally contributes to epilepsy susceptibility.MethodsIndependent ...
Peng Tang, Peng Tang, Xingzhi Guo, Xingzhi Guo, Xingzhi Guo, Li Chong, Li Chong, Rui Li, Rui Li, Rui Li   +9 more
doaj   +1 more source

Identification of and correction for publication bias

, 2017
Some empirical results are more likely to be published than others. Such selective publication leads to biased estimates and distorted inference. This paper proposes two approaches for identifying the conditional probability of publication as a function ...
Andrews, Isaiah, Kasy, Maximilian
core   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source