Results 71 to 80 of about 2,724,889 (347)

Functional Regression [PDF]

, 2014
Functional data analysis (FDA) involves the analysis of data whose ideal units of observation are functions defined on some continuous domain, and the observed data consist of a sample of functions taken from some population, sampled on a discrete grid ...
Morris, Jeffrey S.
core  

A grid-based infrastructure for distributed retrieval [PDF]

, 2007
In large-scale distributed retrieval, challenges of latency, heterogeneity, and dynamicity emphasise the importance of infrastructural support in reducing the development costs of state-of-the-art solutions.
A. Guttman, D. Kossmann, D.C. Blair, F. Simeoni, I. Foster, J. Callan, J. Risson, J.P. Callan, J.P. Callan, L. Si, L. Si, M. Kobayashi, M. Stonebraker, P. Niblett, R.R. Larson, W. Sun, Y. Manolopoulos, Y.E. Ioannidis   +17 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Publication bias is bad for science if not necessarily scientists

Royal Society Open Science
It might seem obvious that the scientific process should not be biased. We strive for reliable inference, and systematically skewing the results of inquiry apparently conflicts with this.
Remco Heesen, Liam Kofi Bright
doaj   +1 more source

Statistical Analysis of a Hybrid Replication Model [PDF]

, 2002
Replication is a technique commonly used to provide high-availability and fault tolerance in distributed systems. With multiple copies of the entities, a service can keep operation even when some copies are inaccessible because of a crash of the computer where a copy was stored, for instance.
Emerson Rogério de Oliveira, Ingrid Jansch Porto   +1 more
openaire   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

RHPMAN: Replication in Highly Partitioned Mobile Ad Hoc Networks

International Journal of Distributed Sensor Networks, 2014
Accessing data in mobile ad hoc networks is a challenging problem, which is caused by frequent network partitions due to node mobility and due to the impairments of wireless communications.
Ke Shi, Hongsheng Chen
doaj   +1 more source

Statistical reform and the replication crisis

, 2018
The replication crisis has prompted many to call for statistical reform within the psychological sciences. Here we examine issues within Frequentist statistics that may have led to the replication crisis, and we examine the alternative---Bayesian statistics---that many have suggested as a replacement.
Colling, Lincoln J, Szucs, Denes
openaire   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Mendelian randomization study shows a causal effect of asthma on epilepsy risk

Frontiers in Immunology, 2023
ObjectiveThe relationship between asthma and epilepsy in observational studies is controversial. The purpose of this Mendelian randomization (MR) study is to investigate whether asthma causally contributes to epilepsy susceptibility.MethodsIndependent ...
Peng Tang, Peng Tang, Xingzhi Guo, Xingzhi Guo, Xingzhi Guo, Li Chong, Li Chong, Rui Li, Rui Li, Rui Li   +9 more
doaj   +1 more source