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Statistics Reform: Practitioner’s Perspective
AppliedMathIt is widely believed that one of the main causes of the replication crisis in scientific research is some of the most commonly used statistical methods, such as null hypothesis significance testing (NHST).
Hening Huang
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What is the probability of replicating a statistically significant effect? [PDF]
Psychonomic Bulletin & Review, 2009 If an initial experiment produces a statistically significant effect, what is the probability that this effect will be replicated in a follow-up experiment? I argue that this seemingly fundamental question can be interpreted in two very different ways and that its answer is, in practice, virtually unknowable under either interpretation.
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
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A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation.
PLoS ONE, 2016 The aims of this systematic review were to determine which blood-based molecules have been evaluated as possible biomarkers to diagnose chronic obstructive pulmonary disease (COPD) exacerbations (AECOPD) and to ascertain the quality of these biomarker ...
Yu-Wei Roy Chen +2 more
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External Replication of Urinary Bladder Cancer Prognostic Polymorphisms in the UK Biobank
Frontiers in Oncology, 2019 Introduction: Multiple studies have reported genetic associations with prognostic outcomes of urinary bladder cancer. However, the lack of replication of these associations prohibits establishing further evidence-based research directions.
Nadezda Lipunova +10 more
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
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An external exposome-wide association study of hypertensive disorders of pregnancy
Environment International, 2020 It is widely recognized that exogenous factors play an important role in the development of hypertensive disorders of pregnancy (HDP). However, only a few external environmental factors have been studied, often separately, with no attempt to examine the ...
Hui Hu +5 more
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Empirical validation of an agent-based model of wood markets in Switzerland. [PDF]
PLoS ONE, 2018 We present an agent-based model of wood markets and show our efforts to validate this model using empirical data from different sources, including interviews, workshops, experiments, and official statistics.
Stefan Holm +3 more
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Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
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Frontiers in Human Neuroscience, 2016 In their innovative study, Inzlicht and Al-Khindi (2012) demonstrated that participants who were allowed to misattribute their arousal and negative affect induced by errors to a placebo beverage had a reduced error-related negativity (ERN/Ne) compared to
Carmen Cano Rodilla +2 more
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