Results 71 to 80 of about 2,618,656 (372)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Identification of and correction for publication bias
, 2017 Some empirical results are more likely to be published than others. Such selective publication leads to biased estimates and distorted inference. This paper proposes two approaches for identifying the conditional probability of publication as a function ...
Andrews, Isaiah, Kasy, Maximilian
core +1 more source
The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. [PDF]
, 2018 PINA is a novel ATPase and DNA helicase highly conserved in Archaea, the third domain of life. The PINA from Sulfolobus islandicus (SisPINA) forms a hexameric ring in crystal and solution.
Ahmad, Sohail +9 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
RHPMAN: Replication in Highly Partitioned Mobile Ad Hoc Networks
International Journal of Distributed Sensor Networks, 2014 Accessing data in mobile ad hoc networks is a challenging problem, which is caused by frequent network partitions due to node mobility and due to the impairments of wireless communications.
Ke Shi, Hongsheng Chen
doaj +1 more source
Predictive mean matching imputation in survey sampling [PDF]
, 2018 Predictive mean matching imputation is popular for handling item nonresponse in survey sampling. In this article, we study the asymptotic properties of the predictive mean matching estimator of the population mean.
Kim, Jae Kwang +2 more
core +3 more sources
Common variants in FOXP1 are associated with generalized vitiligo [PDF]
, 2010 In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent,
A Alkhateeb +34 more
core +2 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Publication bias is bad for science if not necessarily scientists
Royal Society Open ScienceIt might seem obvious that the scientific process should not be biased. We strive for reliable inference, and systematically skewing the results of inquiry apparently conflicts with this.
Remco Heesen, Liam Kofi Bright
doaj +1 more source
Rank Statistics in Biological Evolution
, 2005 We present a statistical analysis of biological evolution processes. Specifically, we study the stochastic replication-mutation-death model where the population of a species may grow or shrink by birth or death, respectively, and additionally, mutations ...
+18 more
core +1 more source