Results 101 to 110 of about 4,294,209 (341)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Self-replicating artificial neural networks give rise to universal evolutionary dynamics.
PLoS Computational BiologyIn evolutionary models, mutations are exogenously introduced by the modeler, rather than endogenously introduced by the replicator itself. We present a new deep-learning based computational model, the self-replicating artificial neural network (SeRANN ...
Boaz Shvartzman, Yoav Ram
doaj +1 more source
An Analysis of the Replicator Dynamics for an Asymmetric Hawk-Dove Game
International Journal of Differential Equations, 2017 We analyze, using a dynamical systems approach, the replicator dynamics for the asymmetric Hawk-Dove game in which there is a set of four pure strategies with arbitrary payoffs.
Ikjyot Singh Kohli, Michael C. Haslam
doaj +1 more source
Replicator dynamics of an N-player snowdrift game with delayed payoffs
Applied Mathematics and Computation, 2021 Thomas A. Wettergren
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Singular equilibrium solutions for a replicator dynamics model
Electronic Journal of Differential Equations, 2011 We evaluate explicitly certain classes of singular equilibrium solutions for a specific one-dimensional replicator dynamics equation. These solutions are linear combinations of Dirac delta functions.
Christos D. Kravvaritis +1 more
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Stability of the replicator dynamics for games in metric spaces
, 2017 In this paper we study the stability of the replicator dynamics for symmetric games when the strategy set is a separable metric space. In this case the replicator dynamics evolves in a space of measures.
Saul Mendoza-Palacios +1 more
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Stable coevolutionary regimes for genetic parasites and their hosts: you must differ to coevolve
Biology Direct, 2018 Background Genetic parasites are ubiquitous satellites of cellular life forms most of which host a variety of mobile genetic elements including transposons, plasmids and viruses.
Faina Berezovskaya +4 more
doaj +1 more source