Results 81 to 90 of about 2,501 (260)

Replication in DHTs Using Dynamic Groups [PDF]

, 2011
Distributed Hash Tables (DHTs) provide an efficient solution for data location and lookup in large-scale P2P systems. However, it is up to the applications to deal with the availability of the data they store in the DHT, e.g. via replication. To improve data availability, most DHT applications rely on data replication.
Akbarinia, Reza, Tlili, Mounir, Pacitti, Esther, Valduriez, Patrick, Lima, Alexandre A. B.   +4 more
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Towards a replicator dynamics model of age structured populations. [PDF]

J Math Biol, 2021
Argasinski K, Broom M.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Blockchain-enabled game-theoretic framework for supply chain finance under information asymmetry [PDF]

تصمیم گیری و تحقیق در عملیات
Purpose: The purpose of this paper is to develop a blockchain-enabled game-theoretic framework that addresses information asymmetry in Supply Chain Finance (SCF). The study aims to model strategic interactions among SCF participants and assess the impact
Yuchuan Bao, Nasyra Ab. Jamil, Hao Ma, Taoyu Chen, Wanling Liang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dynamics of DNA replication: an ultrastructural study

Journal of Structural Biology, 2004
DNA replication in cells takes place in domains scattered throughout the nucleoplasm. We have characterized the dynamics of DNA synthesis in synchronized mid-S-phase HeLa cells. Saponin-permeabilized cells were allowed to elongate nascent DNA chains in presence of biotin-dUTP for 5, 15, and 30 min (a pulse experiment), or for 5 min followed by an ...
Philimonenko, Anatoly A., Jackson, Dean A., Hodný, Zdeněk, Janáček, Jiří, Cook, Peter R., Hozák, Pavel   +5 more
openaire   +2 more sources

Singular equilibrium solutions for a replicator dynamics model

Electronic Journal of Differential Equations, 2011
We evaluate explicitly certain classes of singular equilibrium solutions for a specific one-dimensional replicator dynamics equation. These solutions are linear combinations of Dirac delta functions.
Christos D. Kravvaritis, Vassilis G. Papanicolaou   +1 more
doaj  

Self-replicating artificial neural networks give rise to universal evolutionary dynamics.

PLoS Computational Biology
In evolutionary models, mutations are exogenously introduced by the modeler, rather than endogenously introduced by the replicator itself. We present a new deep-learning based computational model, the self-replicating artificial neural network (SeRANN ...
Boaz Shvartzman, Yoav Ram
doaj   +1 more source