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Replicator dynamics: Old and new
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Biogenesis and Dynamics of the Coronavirus Replicative Structures [PDF]
Coronaviruses are positive-strand RNA viruses that are important infectious agents of both animals and humans. A common feature among positive-strand RNA viruses is their assembly of replication-transcription complexes in association with cytoplasmic membranes.
Hagemeijer, M.C. +2 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Improving replicator dynamic evolutionary game model for selecting optimal defense strategies
In terms of the existence of strategy dependency in the same game group,network attack-defense evolutionary game model based on the improved replicator dynamics was constricted by introducing the intensity coefficient,which completed the method of ...
Jianming HUANG, Hengwei ZHANG
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Decoding the behavioural dynamics of vaccination: how pre-emptive and post-recovery vaccinations shape epidemic outcomes [PDF]
This study presents a coupled behavioural–epidemiological framework that integrates an extended susceptible–infected–recovered–susceptible model with evolutionary game theory to analyse timing-based vaccination strategies, specifically pre-infection and ...
Nihal Majumder, Md. Rajib Arefin
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The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Group Selection Under the Replicator Dynamic
Abstract We consider a society where individuals get divided into different groups, each playing a different strict Nash equilibrium of the same game. Under group selection, a group playing a Nash equilibrium with a higher payoff evolves faster.
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We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source

