Results 91 to 100 of about 30,157 (159)

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

, 2015
The ATR replication checkpoint ensures that stalled forks remain stable when replisome movement is impeded. Using an improved iPOND protocol combined with SILAC mass spectrometry, we characterized human replisome dynamics in response to fork stalling ...
Bhat, Kamakoti P., Cortez, David, Dungrawala, Huzefa, Mohni, Kareem N., Glick, Gloria G., Couch, Frank B., Rose, Kristie L.   +6 more
core   +1 more source

How the eukaryotic replisome achieves rapid and efficient DNA replication

, 2020
The eukaryotic replisome is a molecular machine that coordinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases α, δ, and ε and other proteins to copy the leading- and lagging-strand templates at rates between 1 and 2 kb min-1. We
Joseph TP Yeeles (9131375), Anne Early (8124068), Agnieska Janska (9514349), John FX Diffley (8124071)   +3 more
core  

Single-Molecule DNA Polymerase Dynamics at a Bacterial Replisome in Live Cells

, 2016
PolC is one of two essential replicative DNA polymerases found in the Gram-positive bacterium Bacillus subtilis. The B. subtilis replisome is eukaryotic-like in that it relies on a two DNA polymerase system for chromosomal replication.
Schroeder, Jeremy W., Liao, Yi, Li, Yilai, Biteen, Julie S., Simmons, Lyle A.   +4 more
core   +1 more source

When proteins play tag: the dynamic nature of the replisome

, 2019
DNA replication, or the copying of DNA, is a fundamental process to all life. The system of proteins that carries out replication, the replisome, encounters many roadblocks on its way.
Antonius van Oijen (19587070), Stefan Mueller (19584271), Lisanne Spenkelink (19585807)   +2 more
core   +1 more source

USP37 prevents premature disassembly of stressed replisomes by TRAIP

Nature Communications
The eukaryotic replisome, which consists of the CDC45-MCM2-7-GINS (CMG) helicase, replicative polymerases, and several accessory factors, sometimes encounters proteinaceous obstacles that threaten genome integrity.
Olga V. Kochenova, Giuseppina D’Alessandro, Domenic Pilger, Ernst Schmid, Sean L. Richards, Marcos Rios Garcia, Satpal S. Jhujh, Andrea Voigt, Vipul Gupta, Christopher J. Carnie, R. Alex Wu, Nadia Gueorguieva, Simon Lam, Grant S. Stewart, Johannes C. Walter, Stephen P. Jackson   +15 more
doaj   +1 more source

A new perspective on ATR's role in translesion synthesis. [PDF]

Genes Dev
Lindsey-Boltz LA, Sancar A.
europepmc   +1 more source

Structural and single-molecule insights into the core human mitochondrial DNA replisome. [PDF]

Biochem J
Plaza-G A I, Miguez-Amil S, Hayes AM, Ciesielski GL, Fernandez-Leiro R, Ibarra B.   +5 more
europepmc   +1 more source

Single-molecule tracking of RNA-DNA hybrid removal enzymes important for lagging-strand replication. [PDF]

Biophys J
Foust DJ, Lowder FC, Chung J, Cresti JR, van Gijtenbeek LA, Simmons LA, Biteen JS.   +6 more
europepmc   +1 more source

The nuclear structural protein NuMA is required for efficient DNA replication and supports the association of core replication factors to replication forks. [PDF]

DNA Repair (Amst)
Wang ZG, Knowles S, Wang F, Chai W.
europepmc   +1 more source

Visualizing the interplay of Cas1-Cas2 with DNA replication-repair that creates CRISPR-Cas immunity. [PDF]

Nucleic Acids Res
Hashemloo MA, Killelea T, Mamić T, Ireland TH, Lou-Hing A, Kemm F, Dimude JU, Žagar M, Ivančić-Baće I, Rudolph CJ, Bolt EL.   +10 more
europepmc   +1 more source