Results 81 to 90 of about 30,157 (159)

Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.

PLoS Genetics, 2013
The stabilization of the replisome complex is essential in order to achieve highly processive DNA replication and preserve genomic integrity. Conversely, it would also be advantageous for the cell to abrogate replisome functions to prevent inappropriate ...
Laura C Roseaulin, Chiaki Noguchi, Esteban Martinez, Melissa A Ziegler, Takashi Toda, Eishi Noguchi   +5 more
doaj   +1 more source

Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity

Life Science Alliance, 2019
Analysis of the mitotic replisome disassembly pathway in X. laevis egg extract shows that any replisomes retained on chromatin past S-phase are unloaded through formation of K6- and K63-linked ubiquitin chains on Mcm7 by TRAIP ubiquitin ligase and p97 ...
Sara Priego Moreno, Rebecca M Jones, Divyasree Poovathumkadavil, Shaun Scaramuzza, Agnieszka Gambus   +4 more
doaj   +1 more source

Single-molecule visualization of fast polymerase turnover in the bacterial replisome

eLife, 2017
The Escherichia coli DNA replication machinery has been used as a road map to uncover design rules that enable DNA duplication with high efficiency and fidelity.
Jacob S Lewis, Lisanne M Spenkelink, Slobodan Jergic, Elizabeth A Wood, Enrico Monachino, Nicholas P Horan, Karl E Duderstadt, Michael M Cox, Andrew Robinson, Nicholas E Dixon, Antoine M van Oijen   +10 more
doaj   +1 more source

Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association

Life Science Alliance, 2019
This study suggests a novel role of the telomere-associated human CST complex in suppressing origin licensing, through interactions with MCM, while promoting the recruitment of AND-1 and DNA polymerase alpha for replisome formation. Human CTC1-STN1-TEN1 (
Yilin Wang, Kathryn S Brady, Benjamin P Caiello, Stephanie M Ackerson, Jason A Stewart   +4 more
doaj   +1 more source

Structures and operating principles of the replisome [PDF]

, 2019
Visualization in atomic detail of the replisome that performs concerted leading- and lagging-DNA strand synthesis at a replication fork has not been reported.
Cui, Yanxiang, de Val, Natalia, Lin, Shiqiang, Gao, Yang, Fox, Tara, Wang, Huaibin, Zhou, Z Hong, Yang, Wei   +7 more
core   +1 more source

Dynamics of the Eukaryotic Replicative Helicase at Lagging-Strand Protein Barriers Support the Steric Exclusion Model

Cell Reports, 2019
Summary: Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along the leading-strand template and unwinds the DNA double helix ...
Hazal B. Kose, Nicolai B. Larsen, Julien P. Duxin, Hasan Yardimci   +3 more
doaj   +1 more source

Redox-sensitive alteration of replisome architecture safeguards genome integrity

, 2017
DNA replication requires coordination between replication fork progression and deoxynucleotide triphosphate (dNTP)-generating metabolic pathways. We find that perturbation of ribonucleotide reductase (RNR) in humans elevates reactive oxygen species (ROS)
Rask, Maj-Britt, Ochs, Fena, Fena Ochs, Chunaram Choudhary, Kai John Neelsen, Maj-Britt Rask, Jiri Lukas, Sedlackova, Hana, Lukas, Jiri, Gupta, Rajat, Choudhary, Chunaram, Neelsen, Kai John, Rajat Gupta, Somyajit, Kumar, Hana Sedlackova, Kumar Somyajit   +15 more
core   +1 more source

Two paths to let the replisome go [PDF]

, 2017
Accurate DNA replication is essential for genome mainte- nance. Two recent reports have uncovered new molecular mechanisms controlling the termination phase of DNA replication in higher eukaryotes and established crucial roles for the CRL2LRR1 ubiquitin ...
D'Angiolella, Vincenzo, Daniele Guardavaccaro, Guardavaccaro, Daniele, Vincenzo D'Angiolella   +3 more
core   +2 more sources

Mechanism of replisome-mediated parental histone inheritance

Inheritance of histones from parental DNA during DNA replication is important for the maintenance of epigenetic information and chromatin assembly. Decades of studies have demonstrated that parental histones are symmetrically segregated to the two newly ...
Yu, Juntao
core   +4 more sources

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source