Results 61 to 70 of about 30,157 (159)

The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

Cell Reports, 2019
Summary: Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated (ATM) and ATM and Rad3-related (ATR) dependent DNA damage checkpoint responses.
Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang   +5 more
doaj   +1 more source

Movement of Replicating DNA through a Stationary Replisome

, 2000
We found that DNA is replicated at a central stationary polymerase, and each replicated region moves away from the replisome. In Bacillus subtilis, DNA polymerase is predominantly located at or near midcell.
Grossman, Alan Davis, Katherine P Lemon, Katherine P. Lemon, Alan D. Grossman, Lemon, Katherine P., Alan D Grossman   +5 more
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases

, 2012
The S phase checkpoint pathway preserves genome stability by protecting defective DNA replication forks, but the underlying mechanisms are still understood poorly.
De Piccoli, Giacomo, Nakato, Ryuichiro, Katou, Yuki, Shirahige, Katsuhiko, Itoh, Takehiko, Labib, Karim; id_orcid   +5 more
core   +1 more source

The dynamic nature and territory of transcriptional machinery in the bacterial chromosome

Frontiers in Microbiology, 2015
Our knowledge of the regulation of genes involved in bacterial growth and stress responses is extensive; however, we have only recently begun to understand how environmental cues influence the dynamic, three-dimensional distribution of RNA polymerase ...
Ding Jun Jin, Cedric eCagliero, Carmen eMata Martin, Jerome eIzard, Yan Ning eZhou   +4 more
doaj   +1 more source

Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles

MedComm, Volume 7, Issue 6, June 2026.
This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang, Yu Chen, Xishui Liu, Haowen Lu, Yuqing Yang, Lei Xing, Yu Zhang, Chuandong Lang, Siming Zhang, Shixiang Zhao, Youzhi Hong, Jiaxiang Bai, Yusen Qiao   +12 more
wiley   +1 more source

Human replisome response to short tandem repeats

Short tandem repeats (STRs) are widely distributed repetitive sequences in the human genome. They comprise 1–6 bp motifs repeated in tandem. Due to their repetitive nature, STRs are prone to forming non-canonical DNA secondary structures (including G ...

core   +2 more sources

A common mechanism for recruiting the Rrm3 and RTEL1 accessory helicases to the eukaryotic replisome

The EMBO Journal
The eukaryotic replisome is assembled around the CMG (CDC45-MCM-GINS) replicative helicase, which encircles the leading-strand DNA template at replication forks.
Ottavia Olson, Simone Pelliciari, Emma D Heron, Tom D Deegan   +3 more
doaj   +1 more source

Chromosome segregation in a minimal bacterial cell driven by SMC protein complexes

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Minimal bacterial cells such as JCVI‐Syn3A provide a powerful system for uncovering the essential mechanisms of chromosome organization and segregation. Lacking canonical systems such as Min and ParABS, JCVI‐Syn3A relies primarily on structural maintenance of chromosomes (SMC) protein complexes for partitioning.
Andrew K. Maytin, Benjamin R. Gilbert, Zaida Luthey‐Schulten   +2 more
wiley   +1 more source

The Replisomes Remain Spatially Proximal throughout the Cell Cycle in Bacteria.

PLoS Genetics, 2017
The positioning of the DNA replication machinery (replisome) has been the subject of several studies. Two conflicting models for replisome localization have been proposed: In the Factory Model, sister replisomes remain spatially co-localized as the ...
Sarah M Mangiameli, Brian T Veit, Houra Merrikh, Paul A Wiggins   +3 more
doaj   +1 more source